ArticleCell systems2017
Incoherent Inputs Enhance the Robustness of Biological Oscillators.
Article in Cell systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Design principles for robust multistability in coupled feedforward-feedback regulatory circuits.NPJ systems biology and applications · 2026Article
- Incoherent feedforward loop dominates the robustness and tunability of necroptosis biphasic, emergent, and coexistent dynamics.Fundamental research · 2026Article
- Translating Nature's Design Rules: How Catalysis and Life Science Guide Molecular Catassembly.JACS Au · 2026Review
- Synthetic Cell-Based Approaches to Dissect Autonomous Cellular Oscillators: Recent Applications on the Cell Cycle.Advances in experimental medicine and biology · 2026Review
- Article
- Flexible modulation of hybrid feedback loops in competitive biological oscillators.NPJ systems biology and applications · 2025Article
- Reconstructing gene network structure and dynamics from single cell data.Bioinformatics (Oxford, England) · 2025Article
- Interspecific dispersal constraints suppress pattern formation in metacommunities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Comprehensive Parameter Space Mapping of Cell Cycle Dynamics under Network Perturbations.ACS synthetic biology · 2024Article
- Bayesian Optimization for Design of Multiscale Biological Circuits.ACS synthetic biology · 2023Article
- The ups and downs of biological oscillators: a comparison of time-delayed negative feedback mechanisms.Journal of the Royal Society, Interface · 2023Article
- The Topological Characteristics of Biological Ratio-Sensing Networks.Life (Basel, Switzerland) · 2023Article
- Nuclear-cytoplasmic compartmentalization of cyclin B1-Cdk1 promotes robust timing of mitotic events.Cell reports · 2022Article
- Synthetic robust perfect adaptation achieved by negative feedback coupling with linear weak positive feedback.Nucleic acids research · 2022Article
- Discovering design principles for biological functionalities:Perspectives from systems biology.Journal of biosciences · 2022Review
- Discovering adaptation-capable biological network structures using control-theoretic approaches.PLoS computational biology · 2022Article
- Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast.NPJ systems biology and applications · 2021Review
- Finding gene network topologies for given biological function with recurrent neural network.Nature communications · 2021Article
- Engineering spatiotemporal organization and dynamics in synthetic cells.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Self-assembly-based posttranslational protein oscillators.Science advances · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Robust biological oscillators retain the critical ability to function in the presence of environmental perturbations. Although central architectures that support robust oscillations have been extensively studied, networks containing the same core vary drastically in their potential to oscillate, and it remains elusive what peripheral modifications to the core contribute to this functional variation. Here, we have generated a complete atlas of two- and three-node oscillators computationally, then systematically analyzed the association between network structure and robustness. We found that, while certain core topologies are essential for producing a robust oscillator, local structures can substantially modulate the robustness of oscillations. Notably, local nodes receiving incoherent or coherent inputs respectively promote or attenuate the overall network robustness in an additive manner. We validated these relationships in larger-scale networks reflective of real biological oscillators. Our findings provide an explanation for why auxiliary structures not required for oscillation are evolutionarily conserved and suggest simple ways to evolve or design robust oscillators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.