ArticlePLoS pathogens2017
Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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54 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Modification of Visual Contrast in the Dining Environment and Its Impact on Dietary Intake in Older Adults-A Systematic Review.Nutrients · 2026Pooled it
- Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut.Nature communications · 2021Trial
- Protein Malnutrition Facilitates Intestinal Colonization with Highly ResistantbioRxiv : the preprint server for biology · 2025Article
- Range-Wide Assessment of the Tasmanian Devil Gut Microbiome.Ecology and evolution · 2025Article
- Review
- Impact of Marasmic Malnutrition on Visceral Leishmaniasis: Progression and Treatment Efficacy in a Murine Model.Nutrients · 2025Article
- Giardiavirus infection alleviates growth restriction and intestinal damage caused by the intestinal parasite Giardia duodenalis.Parasites & vectors · 2025Article
- Structure analysis of human gut microbiota associated with single-celled gut protists using Next-Generation Sequencing of 16S and 18S rRNA genes.Computational and structural biotechnology journal · 2025Article
- Giardia lamblia risk factors and burden in children with acute gastroenteritis in a Nicaraguan birth cohort.PLoS neglected tropical diseases · 2024Article
- Mucosal vaccination in a murine gnotobiotic model ofInfection and immunity · 2024Article
- Current Understanding ofCurrent tropical medicine reports · 2024Article
- Article
- Symptomatic and asymptomatic enteric protozoan parasitic infection and their association with subsequent growth parameters in under five children in South Asia and sub-Saharan Africa.PLoS neglected tropical diseases · 2023Article
- Giardia hinders growth by disrupting nutrient metabolism independent of inflammatory enteropathy.Nature communications · 2023Article
- Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection.PLoS pathogens · 2023Article
- Impact of childhood malnutrition and intestinal microbiota on MDR infections.JAC-antimicrobial resistance · 2023Review
- Gut bacteria influence Blastocystis sp. phenotypes and may trigger pathogenicity.PLoS neglected tropical diseases · 2023Article
- Prevalence of diarrheagenic Escherichia coli and impact on child health in Cap-Haitien, Haiti.PLOS global public health · 2023Article
- A framework for testing the impact of co-infections on host gut microbiomes.Animal microbiome · 2022Review
- Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic RegionsMicroorganisms · 2022Article
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14 authors at 5 institutions in 2 countries.
Funding
Abstract
Diverse enteropathogen exposures associate with childhood malnutrition. To elucidate mechanistic pathways whereby enteric microbes interact during malnutrition, we used protein deficiency in mice to develop a new model of co-enteropathogen enteropathy. Focusing on common enteropathogens in malnourished children, Giardia lamblia and enteroaggregative Escherichia coli (EAEC), we provide new insights into intersecting pathogen-specific mechanisms that enhance malnutrition. We show for the first time that during protein malnutrition, the intestinal microbiota permits persistent Giardia colonization and simultaneously contributes to growth impairment. Despite signals of intestinal injury, such as IL1α, Giardia-infected mice lack pro-inflammatory intestinal responses, similar to endemic pediatric Giardia infections. Rather, Giardia perturbs microbial host co-metabolites of proteolysis during growth impairment, whereas host nicotinamide utilization adaptations that correspond with growth recovery increase. EAEC promotes intestinal inflammation and markers of myeloid cell activation. During co-infection, intestinal inflammatory signaling and cellular recruitment responses to EAEC are preserved together with a Giardia-mediated diminishment in myeloid cell activation. Conversely, EAEC extinguishes markers of host energy expenditure regulatory responses to Giardia, as host metabolic adaptations appear exhausted. Integrating immunologic and metabolic profiles during co-pathogen infection and malnutrition, we develop a working mechanistic model of how cumulative diet-induced and pathogen-triggered microbial perturbations result in an increasingly wasted host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.