ArticlePloS one2017
Subclinical thyroid dysfunction and risk of carotid atherosclerosis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Investigating Changes in Cardiac Function and Structure of Left Ventricle by Speckle-Tracking Echocardiography in Patients With Hyperthyroidism and Graves' Disease.Frontiers in cardiovascular medicine · 2021Pooled it
- Thyroid Dysfunction and Atherosclerosis: A Systematic Review.In vivo (Athens, Greece)Pooled it
- Hashimoto's thyroiditis and thyroid hormone sensitivity in euthyroid individuals: their association with carotid plaque in northeast China.Frontiers in endocrinology · 2025Article
- Association between thyroid hormone sensitivity and carotid plaque risk: a health examination cohort-based study.Frontiers in endocrinology · 2024Article
- Deciphering thyroid function and CIMT: a Mendelian randomization study of the U-shaped influence mediated by apolipoproteins.Frontiers in endocrinology · 2024Article
- The relationship between atherosclerotic disease and relapse during ATD treatment.Frontiers in cardiovascular medicine · 2022Article
- Risk of carotid plaques according to triglyceride-glucose index stratified by thyroid function: A cross-sectional study.PloS one · 2022Article
- Unknown Subclinical Hypothyroidism and In-Hospital Outcomes and Short- and Long-Term All-Cause Mortality among ST Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention.Journal of clinical medicine · 2020Article
- Exercise training-induced changes in metabolic syndrome parameters, carotid wall thickness, and thyroid function in middle-aged women with subclinical hypothyroidism.Pflugers Archiv : European journal of physiology · 2019Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of subclinical thyroid dysfunction on vascular atherosclerosis remains uncertain. The objective of this study was to elucidate the association between sustained subclinical thyroid dysfunction and carotid plaques, which are an early surrogate marker of systemic atherosclerosis.
methodsThe study included 21,342 adults with consistent thyroid hormonal status on serial thyroid function tests (TFTs) and carotid artery duplex ultrasonography at a health screening center between 2007 and 2014. The effect of subclinical thyroid dysfunction on baseline carotid plaques and newly developed carotid plaques during 5-year follow-up was determined by logistic regression analyses and GEE (Generalized Estimating Equations), respectively.
resultsCarotid plaques were more common in the subclinical hypothyroidism (55.6%) than the euthyroidism (47.8%) at baseline. However, in multivariable analysis, thyroid status was not a significant risk for the carotid plaques at baseline. Instead, traditional cardiovascular risk factors, such as age (P <0.001), systolic blood pressure (P = 0.023), fasting blood glucose (P = 0.030), and creatinine (P = 0.012) were associated with baseline carotid plaques in subclinical hypothyroidism. In longitudinal analyses of subjects who were followed up for more than 5 years, there was no significant difference in the cumulative incidence of new carotid plaques according to time between subjects with subclinical hypothyroidism and those with euthyroidism (P = 0.392).
conclusionsSustained subclinical thyroid dysfunction did not affect the baseline or development of carotid plaques in healthy individuals.
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