ArticlePloS one2017
From grid cells to place cells with realistic field sizes.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Flexible navigation with neuromodulated cognitive maps.PLoS computational biology · 2026Article
- Cooperative coding of continuous variables in networks with sparsity constraint.PLoS computational biology · 2025Article
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model.Scientific reports · 2022Article
- Adapting hippocampus multi-scale place field distributions in cluttered environments optimizes spatial navigation and learning.Frontiers in computational neuroscience · 2022Article
- A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease.PLoS computational biology · 2021Article
- Distinct place cell dynamics in CA1 and CA3 encode experience in new environments.Nature communications · 2021Article
- A Model of Spatial Cell Development in Rat Hippocampus Based on Artificial Neural Network.Journal of healthcare engineering · 2021Article
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- Learning an Efficient Hippocampal Place Map from Entorhinal Inputs Using Non-Negative Sparse Coding.eNeuroArticle
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While grid cells in the medial entorhinal cortex (MEC) of rodents have multiple, regularly arranged firing fields, place cells in the cornu ammonis (CA) regions of the hippocampus mostly have single spatial firing fields. Since there are extensive projections from MEC to the CA regions, many models have suggested that a feedforward network can transform grid cell firing into robust place cell firing. However, these models generate place fields that are consistently too small compared to those recorded in experiments. Here, we argue that it is implausible that grid cell activity alone can be transformed into place cells with robust place fields of realistic size in a feedforward network. We propose two solutions to this problem. Firstly, weakly spatially modulated cells, which are abundant throughout EC, provide input to downstream place cells along with grid cells. This simple model reproduces many place cell characteristics as well as results from lesion studies. Secondly, the recurrent connections between place cells in the CA3 network generate robust and realistic place fields. Both mechanisms could work in parallel in the hippocampal formation and this redundancy might account for the robustness of place cell responses to a range of disruptions of the hippocampal circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.