SynthesisPloS one2017
Pediatric cancer risk in association with birth defects: A systematic review.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study.Pediatric blood & cancer · 2026Article
- Cancer risk in children with congenital anomalies.Nature reviews. Cancer · 2026Article
- Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Neuroblastoma Presenting as a Congenital Renal Mass in a Neonate: A Diagnostic Pitfall.Children (Basel, Switzerland) · 2026Article
- Risk of Childhood Cancer in Children with Congenital Anomalies and Their Impact on Survival: A Population-Based Registry Approach.Current oncology (Toronto, Ont.) · 2025Article
- Review
- Co-occurrence of congenital anomalies and childhood brain tumors in 22 million live births.Neuro-oncology · 2025Article
- Adult-onset medulloblastoma presenting in the setting of untreated spina bifida: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- The global, regional, and national brain and central nervous system cancer burden and trends from 1990 to 2021: an analysis based on the Global Burden of Disease Study 2021.Frontiers in neurology · 2025Article
- Article
- Inequities in childhood cancer research: A scoping review.EJC paediatric oncology · 2024Article
- Article
- Causes of Childhood Cancer: A Review of the Recent Literature: Part I-Childhood Factors.Cancers · 2024Review
- Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium.International journal of cancer · 2024Article
- Associations between birth defects with neural crest cell origins and pediatric embryonal tumors.Cancer · 2023Article
- Using existing pediatric cancer data from the Gabriella Miller Kids First Data Resource Program.JNCI cancer spectrum · 2023Article
- Article
- Sex differences in childhood cancer risk among children with major birth defects: a Nordic population-based nested case-control study.International journal of epidemiology · 2023Article
- The risks of birth defects and childhood cancer with conception by assisted reproductive technology.Human reproduction (Oxford, England) · 2022Article
- The relationship between congenital heart disease and cancer in Swedish children: A population-based cohort study.PLoS medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany epidemiological studies have examined associations between birth defects (BDs) and pediatric malignancy over the past several decades. Our objective was to conduct a systematic literature review of studies reporting on this association.
methodsWe used librarian-designed searches of the PubMed Medline and Embase databases to identify primary research articles on pediatric neoplasms and BDs. English language articles from PubMed and Embase up to 10/12/2015, and in PubMed up to 5/12/2017 following an updated search, were eligible for inclusion if they reported primary epidemiological research results on associations between BDs and pediatric malignancies. Two reviewers coded each article based on the title and abstract to identify eligible articles that were abstracted using a structured form. Additional articles were identified through reference lists and other sources. Results were synthesized for pediatric cancers overall and for nine major pediatric cancer subtypes.
resultsA total of 14,778 article citations were identified, of which 80 met inclusion criteria. Pediatric cancer risk was increased in most studies in association with BDs overall with some notable specific findings, including increased risks for CNS tumors in association with CNS abnormalities and positive associations between rib anomalies and several pediatric cancer types.
conclusionsSome children born with BDs may be at increased risk for specific pediatric malignancy types. This work provides a foundation for future investigations that are needed to clarify specific BD types predisposing toward malignancy and possible underlying causes of both BDs and malignancy.
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