ArticlePLoS computational biology2017
Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
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- Firing rate distributions in plastic networks of spiking neurons.Network neuroscience (Cambridge, Mass.) · 2025Article
- Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation.Frontiers in neuroscience · 2025Article
- Highly Customizable 3D Microelectrode Arrays for In Vitro and In Vivo Neuronal Tissue Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Engineering the structural and electrical interplay of nanostructured Au resistive switching networks by controlling the forming process.Scientific reports · 2023Article
- Structural Modularity Tunes Mesoscale Criticality in Biological Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning.Frontiers in neuroscience · 2022Article
- A novel methodology to describe neuronal networks activity reveals spatiotemporal recruitment dynamics of synchronous bursting states.Journal of computational neuroscience · 2021Article
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
- Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regional NeurodegenerationFrontiers in computational neuroscience · 2021Article
- Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease.BMC biology · 2020Article
- Relating network connectivity to dynamics: opportunities and challenges for theoretical neuroscience.Current opinion in neurobiology · 2019Review
- Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength.Molecular neurobiology · 2019Article
- Inhomogeneities in Network Structure and Excitability Govern Initiation and Propagation of Spontaneous Burst Activity.Frontiers in neuroscience · 2019Article
- Hindbrain V2a Neurons Pattern Rhythmic Activity of Motor Neurons in a Reticulospinal Coculture.Frontiers in neuroscience · 2019Article
- Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks.Frontiers in cellular neuroscience · 2019Article
- Assessing functional connectivity across 3D tissue engineered axonal tracts using calcium fluorescence imaging.Journal of neural engineering · 2018Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developing neuronal systems intrinsically generate coordinated spontaneous activity that propagates by involving a large number of synchronously firing neurons. In vivo, waves of spikes transiently characterize the activity of developing brain circuits and are fundamental for activity-dependent circuit formation. In vitro, coordinated spontaneous spiking activity, or network bursts (NBs), interleaved within periods of asynchronous spikes emerge during the development of 2D and 3D neuronal cultures. Several studies have investigated this type of activity and its dynamics, but how a neuronal system generates these coordinated events remains unclear. Here, we investigate at a cellular level the generation of network bursts in spontaneously active neuronal cultures by exploiting high-resolution multielectrode array recordings and computational network modelling. Our analysis reveals that NBs are generated in specialized regions of the network (functional neuronal communities) that feature neuronal links with high cross-correlation peak values, sub-millisecond lags and that share very similar structural connectivity motifs providing recurrent interactions. We show that the particular properties of these local structures enable locally amplifying spontaneous asynchronous spikes and that this mechanism can lead to the initiation of NBs. Through the analysis of simulated and experimental data, we also show that AMPA currents drive the coordinated activity, while NMDA and GABA currents are only involved in shaping the dynamics of NBs. Overall, our results suggest that the presence of functional neuronal communities with recurrent local connections allows a neuronal system to generate spontaneous coordinated spiking activity events. As suggested by the rules used for implementing our computational model, such functional communities might naturally emerge during network development by following simple constraints on distance-based connectivity.
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