ArticleEnvironmental health perspectives2017
Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Childhood PFAS exposure and immunotoxicity: a systematic review and meta-analysis of human studies.Systematic reviews · 2024Pooled it
- Per- and Poly-fluoroalkyl Substances (PFAS) Exposure and Risk of Kidney, Liver, and Testicular Cancers: A Systematic Review and Meta-Analysis.La Medicina del lavoro · 2023Pooled it
- The effects of exposures to mycotoxins on immunity in children: A systematic review.Current problems in pediatric and adolescent health care · 2019Pooled it
- Derivation of guidance values under the EU Drinking Water Directive : the case study of trifluoroacetic acid.Archives of toxicology · 2026Review
- In Utero Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Changes in Infant T Helper Cell Development among UPSIDE-ECHO Cohort Participants.Environmental health perspectives · 2026Article
- Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and childhood vaccine-induced immunity.Environmental health : a global access science source · 2026Article
- A Network Toxicology Framework for Identification of Immune System Disruption by Per- and Polyfluoroalkyl Substance (PFAS) Mixture: In Silico Analysis.Journal of xenobiotics · 2026Article
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- Article
- Associations of mid-childhood per- and polyfluoroalkyl substances and early childhood metals with mid-childhood antibody titers.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- SARS-CoV-2 Anti-Spike IgG Subclass Titres in a Population with Prior Exposure to Perfluorooctanoic Acid (PFOA).Toxics · 2026Article
- HIDmap: a physiology-based map of human immune system development to support animal-free research and regulatory innovation.Frontiers in immunology · 2026Article
- Models and challenges for studying forever chemicals and their impact on human health.Disease models & mechanisms · 2025Review
- Review
- The PFAS Conundrum-Of Logic, Science, Policy.Toxics · 2025Article
- The Impact of Perfluoroalkyl Substances on the Clinical Manifestations of Primary Sjögren Syndrome.Toxics · 2025Article
- Elevated per- and polyfluoroalkyl substances (PFASs) in tap water and serum in a community near an abandoned paper mill.Environmental advances · 2025Article
- Evaluation of the exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) through drinking water and human risk assessment.Journal of environmental health science & engineering · 2025Article
- Exposure to Legacy Per- and Polyfluoroalkyl Substances from Diet and Drinking Water in California Adults, 2018-2020.Environmental science & technology · 2025Article
- In vitro approaches to investigate the effect of chemicals on antibody production: the case study of PFASs.Archives of toxicology · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundPostnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concentrations of specific antibodies against certain childhood vaccines at 7 y.
objectivesWe prospectively followed a Faroese birth cohort to determine these associations at 13 y.
methodsIn 516 subjects (79% of eligible cohort members) who were 13 years old, serum concentrations of PFASs and of antibodies against diphtheria and tetanus were measured and were compared with data from the previous examination at 7 y. Multiple regression analyses and structural equation models were applied to determine the association between postnatal PFAS exposures and antibody concentrations.
resultsSerum concentrations of PFASs and antibodies generally declined from 7 y to 13 y. However, 68 subjects had visited the emergency room and had likely received a vaccination booster, and a total of 202 children showed higher vaccine antibody concentrations at 13 y than at 7 y. Therefore, separate analyses were conducted after exclusion of these two subgroups. Diphtheria antibody concentrations decreased at elevated PFAS concentrations at 13 y and 7 y; the associations were statistically significant for perfluorodecanoate (PFDA) at 7 y and for perfluorooctanoate (PFOA) at 13 y, both suggesting a decrease by ∼25% for each doubling of exposure. Structural equation models showed that a doubling in PFAS exposure at 7 y was associated with losses in diphtheria antibody concentrations at 13 y of 10–30% for the five PFASs. Few associations were observed for anti-tetanus concentrations.
conclusionsThese results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.