Evidence map›Paper›PMID 28749671›Full record

ArticleJournal of natural products2017

Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.

Liangxiong Xu, Ping Wu, Jinghua Xue, Istvan Molnar, Xiaoyi Wei

Abstract read
In one paragraph

Article in Journal of natural products, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. The Effect of Cyclosporin A onFoods (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Secondary Metabolites and Their Bioactivities Produced byMolecules (Basel, Switzerland) · 2020
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liangxiong XuKey Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
Ping WuKey Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
Jinghua XueKey Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
Istvan MolnarNatural Products Center, School of Natural Resources and the Environment, University of Arizona , Tucson, Arizona 85706, United States.ORCID 0000-0002-3627-0454
Xiaoyi WeiKey Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.ORCID 0000-0002-4053-6999

Funding

Combinatorial biosynthesis of fungal benzenediol lactone polyketidesR01GM114418 · NIGMS · UNIVERSITY OF ARIZONA · PI MOLNAR, ISTVAN · 2016 to 2019
$1.4M
NIGMS NIH HHS R01 GM114418
6 · The paper itself

Abstract

Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.

Indexed as

Antifungal AgentsHeLa CellsHumansHydroxybenzoate EthersHydroxybenzoatesLactonesMacrolidesMolecular StructurePaecilomycesPhytophthoraX-Ray DiffractionZearalenoneAntifungal Agentsbeta-resorcylic acidHydroxybenzoate EthersHydroxybenzoateshypothemycinLactonesMacrolidesmonordenpaecilomycin-Npaecilomycin-Opaecilomycin-PZearalenone

Identifiers

PMID28749671
PMCPMC5819736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.