ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Caffeine decreases intermittent hypoxia in preterm infants nearing term-equivalent age.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03321734 (Intermittent Hypoxia and Caffeine in Infants Born Preterm), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intermittent Hypoxia and Caffeine in Infants Born Preterm (ICAF)
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Strategies for caffeine administration in preterm infants: route, dosing, monitoring, and adjunctive interventions - a systematic review.Italian journal of pediatrics · 2026Pooled it
- Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.Archives of disease in childhood. Fetal and neonatal edition · 2026Trial
- Adverse effects of COVID-19 pandemic on a multicenter randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Association Between Serum Caffeine Concentrations, Intermittent Hypoxia and Apnea in Preterm Infants: A Prospective Observational Study.Children (Basel, Switzerland) · 2026Article
- Caffeine for Persistent Intermittent Hypoxia in Newborns With and Without Chronic Lung Disease.Pediatric pulmonology · 2025Article
- Impact of cessation of caffeine citrate therapy on intermittent hypoxemia patterns among preterm infants born before 34 weeks.Frontiers in pediatrics · 2025Article
- Caffeine use in preterm neonates: national insights into Turkish NICU practices.Frontiers in pediatrics · 2025Article
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Caffeine: The Story beyond Oxygen-Induced Lung and Brain Injury in Neonatal Animal Models-A Narrative Review.Antioxidants (Basel, Switzerland) · 2024Review
- Plasma serotonergic biomarkers are associated with hypoxemia events in preterm neonates.Pediatric research · 2023Article
- Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants.American journal of respiratory and critical care medicine · 2023Article
- Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity.The Cochrane database of systematic reviews · 2023Review
- Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.Frontiers in pharmacology · 2022Review
- Immature control of breathing and apnea of prematurity: the known and unknown.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Neuromodulatory Support for Breathing and Cardiovascular Action During Development.Frontiers in pediatrics · 2021Review
- Encephalopathy in Preterm Infants: Advances in Neuroprotection With Caffeine.Frontiers in pediatrics · 2021Review
- Discharging Preterm Infants Home on Caffeine, a Single Center Experience.Children (Basel, Switzerland) · 2020Article
- Postmenstrual age at discharge in premature infants with and without ventilatory pattern instability.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Caffeine: an evidence-based success story in VLBW pharmacotherapy.Pediatric research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether intermittent hypoxia (IH) persisting after 36 weeks postmenstrual age (PMA) can be attenuated using caffeine doses sufficient to maintain caffeine concentrations >20 μg ml STUDY
designTwenty-seven infants born <32 weeks were started on caffeine citrate at 10 mg kg
resultThe mean (s.d.) gestational age of enrolled infants was 27.9±2 weeks. Median caffeine levels were >20 μg ml
conclusionCaffeine doses of 14 to 20 mg kg
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.