ArticleSensors (Basel, Switzerland)2017
Evaluation of Shifted Excitation Raman Difference Spectroscopy and Comparison to Computational Background Correction Methods Applied to Biochemical Raman Spectra.
Article in Sensors (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- An Integrated Raman Platform with Embedded AI for Intraoperative Real-Time Cancer Detection.Analytical chemistry · 2026Article
- Ecology-microbiome engineering in Sauce-flavor Baijiu via Single-Cell Raman Spectroscopy.Biodesign research · 2026Review
- Asymmetric Dimethylarginine Vibrational Spectroscopy Spectra and Density Functional Theory Model.Sensors (Basel, Switzerland) · 2025Article
- Artifacts and Anomalies in Raman Spectroscopy: A Review on Origins and Correction Procedures.Molecules (Basel, Switzerland) · 2024Review
- Employing Raman Spectroscopy and Machine Learning for the Identification of Breast Cancer.Biological procedures online · 2024Article
- Binding Mechanism and Surface-Enhanced Raman Scattering of the Antimicrobial Sulfathiazole on Gold Nanoparticles.ACS omega · 2023Article
- Emergence of Raman Spectroscopy as a Probing Tool for Theranostics.Nanotheranostics · 2023Review
- Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications.Journal of biomedical optics · 2021Review
- Gold nanoclusters as prospective carriers and detectors of pramipexole.RSC advances · 2021Article
- Wide Field Spectral Imaging with Shifted Excitation Raman Difference Spectroscopy Using the Nod and Shuffle Technique.Sensors (Basel, Switzerland) · 2020Article
- FLIm and Raman Spectroscopy for Investigating Biochemical Changes of Bovine Pericardium upon Genipin Cross-Linking.Molecules (Basel, Switzerland) · 2020Article
- Bladder tissue characterization using probe-based Raman spectroscopy: Evaluation of tissue heterogeneity and influence on the model prediction.Journal of biophotonics · 2020Article
- Parallelized shifted-excitation Raman difference spectroscopy for fluorescence rejection in a temporary varying system.Journal of biophotonics · 2019Article
- Application of High-Throughput Screening Raman Spectroscopy (HTS-RS) for Label-Free Identification and Molecular Characterization of Pollen.Sensors (Basel, Switzerland) · 2019Article
- Surface-Enhanced Raman Scattering Detection of Fipronil Pesticide Adsorbed on Silver Nanoparticles.Sensors (Basel, Switzerland) · 2019Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. However, a challenge for in vivo applications is the simultaneous excitation of auto-fluorescence in the majority of tissues of interest, such as liver, bladder, brain, and others. Raman bands are then superimposed on a fluorescence background, which can be several orders of magnitude larger than the Raman signal. To eliminate the disturbing fluorescence background, several approaches are available. Among instrumentational methods shifted excitation Raman difference spectroscopy (SERDS) has been widely applied and studied. Similarly, computational techniques, for instance extended multiplicative scatter correction (EMSC), have also been employed to remove undesired background contributions. Here, we present a theoretical and experimental evaluation and comparison of fluorescence background removal approaches for Raman spectra based on SERDS and EMSC.
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