ArticleInternational journal of molecular sciences2017
Effects of Melatonin on Early Pregnancy in Mouse: Involving the Regulation of StAR, Cyp11a1, and Ihh Expression.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.BMC veterinary research · 2026Article
- Exploring melatonin's multifaceted role in female reproductive health: From follicular development to lactation and its therapeutic potential in obstetric syndromes.Journal of advanced research · 2025Review
- The impact of seasonal variations on IVF pregnancy outcomes: a retrospective cohort study in Jinan, China.Frontiers in medicine · 2025Article
- Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.Life medicine · 2024Article
- Melatonin Sources in Sheep Rumen and Its Role in Reproductive Physiology.Animals : an open access journal from MDPI · 2024Article
- Role of Melatonin in Ovarian Function.Animals : an open access journal from MDPI · 2024Review
- Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.Pharmaceutical biology · 2022Article
- Melatonin is involved in the modulation of the hypothalamic and pituitary activity in the South American plains vizcacha, Lagostomus maximus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Melatonin for premenstrual syndrome: A potential remedy but not ready.Frontiers in endocrinology · 2022Review
- Differences in gene expression and variable splicing events of ovaries between large and small litter size in Chinese Xiang pigs.Porcine health management · 2021Article
- Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression.International journal of molecular sciences · 2021Review
- Expression of melatonin receptors and CD4 in the ovine thymus, lymph node, spleen and liver during early pregnancy.Immunology · 2020Article
- Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.EBioMedicine · 2020Article
- Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms.International journal of molecular sciences · 2019Review
- Article
- Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness.Stem cell research & therapy · 2019Article
- From Implantation to Birth: Insight into Molecular Melatonin Functions.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To test whether melatonin plays an important role in the process of early pregnancy, melatonin was given in drinking water to pregnant mice at different gestation stages. These included mice who were given melatonin 14 days prior to their successful mating (confirmed by vaginal plug) (Group A), after successful mating (Group B), and 14 days prior to and until after successful mating (Group C). Melatonin administration significantly enhanced serum as well as ovarian melatonin levels in the mice. It was observed that melatonin did not affect the natural estrous of mice. On day 0.5 of gestation (D0.5), melatonin not only elevated progesterone (P) secretion, but also upregulated expressions of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.