Evidence map›Paper›PMID 28749403›Full record

ArticleThe Indian journal of medical research2017

HIV-malaria interactions in North-East India: A prospective cohort study.

Pradhyumn K Mohapatra, Elsa Pachuau, Chandra Kumar, Biswajit Borkakoty, Eric Zomawia, Achouba Singh, Kamini Walia, Rashmi Arora, Jagdish Mahanta, Sarala K Subbarao

Open access · diamondAbstract read
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Article in The Indian journal of medical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Pradhyumn K MohapatraRegional Medical Research Centre (ICMR), Dibrugarh, India.
Elsa PachuauDepartment of Pathology, Civil Hospital, Aizawl, India.
Chandra KumarDepartment of Community Medicine, Regional Institute of Medical Sciences, Imphal, India.
Biswajit BorkakotyRegional Medical Research Centre (ICMR), Dibrugarh, India.
Eric ZomawiaDepartment of Pathology, Civil Hospital, Aizawl, India.
Achouba SinghDepartment of Community Medicine, Regional Institute of Medical Sciences, Imphal, India.
Kamini WaliaDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Rashmi AroraDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Jagdish MahantaRegional Medical Research Centre (ICMR), Dibrugarh, India.
Sarala K SubbaraoDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
Indian Council of Medical Research · INRegional Medical Research Centre · INAizawl Adventist Hospital · INRegional Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesThe interactions between HIV and malaria co-infection have been shown to influence each other in their clinical outcomes in Sub-Saharan Africa. This study was carried out in the two States of north east India endemic for both HIV and malaria infections, to study the interactions between the two diseases in the HIV-infected population.

methodsIn this prospective study, a total of 333 HIV-infected individuals were followed up for a period of 6-18 months in Mizoram and Manipur during 2010-2011. The study assessed the changes in viral load and also the therapeutic efficacy of artesunate plus sulphadoxine-pyrimethamine (AS+SP) combination therapy in HIV-infected and HIV-uninfected individuals with Plasmodium falciparum malaria.

resultsViral load in HIV-infected malaria patients on day zero (D0) ranged from 1110 to 147,000 copies/ml. The log transformation of the geometric means of HIV viral loads revealed no significant difference on different days of follow up. There was 100 per cent adequate clinical and parasitological response (ACPR) after treating with artemisinin based combination therapy (ACT) both in HIV-infected and HIV-uninfected P. falciparum-positive individuals. Similarly, chloroquine showed 100 per cent ACPR in P. vivax HIV-infected individuals. INTERPRETATION &

conclusionThe study showed no significant increase in HIV viral load in malaria cases. All HIV-infected and HIV-uninfected P. falciparum malaria-positive cases responded to the treatment with 100 per cent ACPR.

Indexed as

AdolescentAdultAntimalarialsChild, PreschoolChloroquineCoinfectionDrug ResistanceFemaleHIV InfectionsHumansMalaria, FalciparumMalaria, VivaxMalePlasmodium falciparumViral LoadAntimalarialsChloroquine

Identifiers

PMID28749403
PMCPMC5555069
OpenAlexW2891427246

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.