ArticleAsian Pacific journal of cancer prevention : APJCP2017
Antitumor Exopolysaccharides Derived from Novel Marine Bacillus: Isolation, Characterization Aspect and Biological Activity
Article in Asian Pacific journal of cancer prevention : APJCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Bacillus mojavensis postbiotics: transcriptomic and anticancer effects in colon cancer cells.AMB Express · 2026Article
- Enhancing the in vitro anticancer efficacy of Paclitaxel against triple-negative breast cancer via an exopolysaccharide from a haloalkaliphilic archaeal strain.Scientific reports · 2025Article
- β-(1 → 3) Linked Sulfated Polygalactan from a Seaweed-associated Bacillus velezensis MTCC 13097: A Potential Lead Against Human Hepatocellular Adenocarcinoma.Marine biotechnology (New York, N.Y.) · 2025Article
- Marine-Derived Polysaccharides and Their Potential Health Benefits in Nutraceutical Applications.Marine drugs · 2025Review
- Anticancer and Antioxidant Activities of Rhizospheric Soil Bacteria ofInternational journal of microbiology · 2025Article
- Halotolerant Endophytic BacteriaMicroorganisms · 2024Article
- Identification and characterization of a marine bacterium extract from Mameliella sp. M20D2D8 with antiviral effects against influenza A and B viruses.Archives of virology · 2024Article
- Appraisal of postbiotics in cancer therapy.Frontiers in pharmacology · 2024Review
- Marine Microbial Polysaccharides: An Untapped Resource for Biotechnological Applications.Marine drugs · 2023Review
- Exopolysaccharide Production from Marine-DerivedMarine drugs · 2023Article
- Characterization and in vitro anticancer potential of exopolysaccharide extracted from a freshwater diatom Nitzschia palea (Kütz.) W.Sm. 1856.Scientific reports · 2022Article
- Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies.Marine drugs · 2022Review
- Potential functions and applications of diverse microbial exopolysaccharides in marine environments.Journal, genetic engineering & biotechnology · 2022Review
- Molecular Characterization and Biocompatibility of Exopolysaccharide Produced by Moderately Halophilic BacteriumPolymers · 2022Article
- Synthesis and Rheological Characterization of a Novel Salecan Hydrogel.Pharmaceutics · 2022Article
- Bacterial polysaccharides-A big source for prebiotics and therapeutics.Frontiers in nutrition · 2022Review
- Therapeutic applications and biological activities of bacterial bioactive extracts.Archives of microbiology · 2021Review
- New combination approaches to combat methicillin-resistant Staphylococcus aureus (MRSA).Scientific reports · 2021Article
- Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides fromMarine drugs · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Exopolysaccharides gained attention as new source for cancer treatment as recent treatments cause side effects and multidrug resistance. Polysaccharides containing sulfur and uronic acids exhibited antioxidant activity, by restoring cell redox regulation, thus inhibiting cell proliferation and cancer formation. Following this context, our study was performed to assess the cytotoxic activity of exopolysaccharides produced by novel Egyptian marine bacterial strains on HepG2 cells. Methods: Bacteria were isolated, purified and cultured through routine microbiological techniques. 16S rRNA gene amplification and sequence analyses, Fourier Transform Infra-red (FTIR), Identification of monosugars by HPLC molecular weight estimation, sulfur content determination and neutral red uptake assay were utilized. Results: BLAST showed that the isolates were related to the Bacillus sp. FTIR analysis indicated that the four EPSs under study contained sulfur as substituent functional group but with different percentage in each EPS. The highest sulfur percentage (46%) appeared in the EPS-6 that was produced by Bacillus flexus isolated from the Mediterranean Sea. HPLC showed that EPSs contained uronic acids which appeared as glucuronic and galacturonic acid in the low molecular weight EPS-6 (4.296×104 g mol-1). Arabinose appeared besides the glucuronic and galacturonic acid residues. EPS-6 showed the highest cytotoxicity, IC50 (218 μg ml-1) which could be correlated to the presence of sulfure and uronic acids in its structure. Conclusion: The novel Firmicutes from the Egyptian saline habitat produced EPSs of cytotoxic activity on hepatocellular carcinoma.
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