ArticleAsian Pacific journal of cancer prevention : APJCP2017
Platelet Distribution Width and Serum Albumin Levels for Discrimination of Thyroid Cancer From Benign Thyroid Nodules
Article in Asian Pacific journal of cancer prevention : APJCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A novel marker for predicting malignancy in patients with thyroid nodules diagnosed as AUS on initial cytology: thyroid hormone sensitivity.Frontiers in endocrinology · 2026Article
- Platelet Indices as a Biomarker in Distinguishing Benign and Malignant Breast Lesions.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Copper/zinc ratio and erythrocyte superoxide dismutase in patients with thyroid nodules.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2021Article
- Relationship of the platelet distribution width/platelet count ratio with thyroid antibody levels in patients with Hashimoto's thyroiditis.The Journal of international medical research · 2021Article
- Can preoperative modified systemic inflammation score (mSIS) be used to predict malignancy in persistent nondiagnostic thyroid nodules?Turkish journal of medical sciences · 2021Article
- Evaluation of platelet distribution width as novel biomarker in gall bladder cancer.Journal of carcinogenesis · 2020Article
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8 authors.
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Abstract
Thyroid cancer is the most rapidly increasing cancer type among women and the second among men. Early detection greatly improves the prognosis. For this purpose, the platelet distribution width (PDW), an early indicator of platelet activation, might be useful. The aim of this study was to investigate the ability of PDW and serum albumin levels individually or in combination to distinguish between thyroid cancer and benign thyroid nodules. A total of 265 patients with thyroid cancer and 243 with benign thyroid nodules were included in a development set. Then, two groups of 130 cases were enrolled in a validation set. Patient characteristics and hematologic test data at initial diagnosis were collected. Receiver operating characteristic curves (ROC), area under the curve (AUC) values, sensitivity and specificity were estimated. Albumin levels are significantly lower and PDW significantly higher in patients with thyroid cancer compared to the benign cases. Moreover, PDW values prominently differed among three types of thyroid cancer. In addition, the combination of PDW and albumin exhibited a significantly larger AUC than either marker alone (p < 0.001). In conclusion, the combined use of PDW and albumin might be useful in distinguishing thyroid cancer from benign thyroid nodules. This promising approach could be helpful in early detection of thyroid cancer.
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