ArticleActa pharmacologica Sinica2017
Association of bone turnover markers with glucose metabolism in Chinese population.
Article in Acta pharmacologica Sinica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Association of Different Patterns of Insulin Resistance With Miscarriage in Population With Miscarriage History: a Multicenter Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- The impact of dyslipidemia on skeletal health - from an immunoregulatory perspective.Frontiers in immunology · 2026Review
- Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study.Cell reports. Medicine · 2025Article
- Relationship between bone turnover markers and diabetic kidney disease in patients with type 2 diabetes.Frontiers in endocrinology · 2025Article
- Research progress of circRNA as a biomarker of osteoporosis.Frontiers in genetics · 2024Review
- Association of Bone Turnover Markers with Type 2 Diabetes Mellitus and Microvascular Complications: A Matched Case-Control Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Improvement of Lipotoxicity-Induced IsletJournal of diabetes research · 2022Article
- Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus.Frontiers in cardiovascular medicine · 2022Article
- Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study.International journal of endocrinology · 2021Article
- First-degree family history of diabetes and its relationship with serum osteocalcin levels independent of liver fat content in a non-diabetic Chinese cohort.BMC public health · 2019Article
- The Endocrine Role of Bone in Cardiometabolic Health.Current nutrition reports · 2019Review
- Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population.Acta pharmacologica Sinica · 2018Observational
- INSULIN RESISTANCE AND PATHOGENESIS OF POSTMENOPAUSAL OSTEOPOROSIS.Acta endocrinologica (Bucharest, Romania : 2005)Review
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The association between type 2 diabetes (T2DM) and bone metabolism has been discussed previously but is controversial. In this study we aimed to evaluate the association of bone turnover markers with glucose metabolism in Chinese population, in which 919 males and 4171 postmenopausal females in a region of Shanghai were recruited. Anthropometric and biochemical traits related to glucose and bone metabolism were analyzed. Participants were classified according to their glucose tolerance as normal glucose tolerance (NGT), impaired glucose regulation (IGR) or T2DM. Males and females were analyzed separately, and then associations between bone turnover markers (BTMs) and glucose metabolism were evaluated. The results showed that in females, the serum levels of N-terminal osteocalcin (N-MID), N-terminal procollagen of type I collagen (PINP) and β-cross-linked C-telopeptide of type I collagen (β-CTX) were significantly decreased in the T2DM group compared to the NGT group (P<0.01). When age, body mass index, serum lipids, fat percentage, visceral fat area, subcutaneous fat area, anti-diabetic medicines, PINP, N-MID and β-CTX were included in one logistic model, N-MID (OR [95% CI]: 0.954 [0.932; 0.976]; P=0.0001) was significantly associated with T2DM in females. In females, N-MID was associated with insulin sensitivity and HOMA-β. PINP was significantly associated with HOMA-β, GUTT-ISI, Stumvoll first-phase insulin secretion index (STU-1) and Stumvoll second-phase insulin secretion index (STU-2), but β-CTX was associated only with HOMA-β (β±SE: 0.1331±0.0311; P=1.95×10
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