ArticleActa pharmacologica Sinica2018
D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress.
Article in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Hepatoprotective Activity of the Fruits ofNutrients · 2025Article
- Effects of bitter almond on production performance, antioxidant capacity and immune function of Rongde black-feathered small-sized layer strain.Frontiers in veterinary science · 2025Article
- Antioxidant and hepatoprotective activities ofResearch in pharmaceutical sciences · 2024Article
- Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease?Food science & nutrition · 2024Article
- Efficiency of Hesperidin against Liver Fibrosis Induced by Bile Duct Ligation in Rats.BioMed research international · 2023Article
- The Protective Effects ofBioMed research international · 2022Article
- The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the striatum of male Wistar rats.Metabolic brain disease · 2021Article
- Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats.Oxidative medicine and cellular longevity · 2021Article
- Antioxidant and Anti-Inflammatory Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway.Cell & bioscience · 2020Article
- Metformin attenuates oxidative stress and liver damage after bile duct ligation in rats.Research in pharmaceutical sciences · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholestatic liver diseases are important causes of liver cirrhosis and liver transplantation, but few drugs are available for treatment. D-chiro-inositol (DCI), an isomer of inositol found in many Leguminosae plants and in animal viscera, is used clinically for the treatment of polycystic ovary syndrome (PCOS) and diabetes mellitus. In this study, we investigated whether DCI exerted an anti-cholestatic effect and its underlying mechanisms. A cholestatic rat model was established via bile duct ligation (BDL). After the surgery, the rats were given DCI (150 mg·kg
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