Evidence map›Paper›PMID 28748662›Full record

ArticleJournal of medical primatology2017

Repeated administration of high-dose depot medroxyprogesterone acetate does not alter SHIV

Priya Srinivasan, Jining Zhang, Chuong T Dinh, Ryan S Teller, Janet M McNicholl, Patrick F Kiser, Betsy C Herold, James M Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Priya SrinivasanCenters for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0001-8426-6532
Jining ZhangTotal Solutions Inc., Atlanta, GA, USA.
Chuong T DinhCenters for Disease Control and Prevention, Atlanta, GA, USA.
Ryan S TellerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Janet M McNichollCenters for Disease Control and Prevention, Atlanta, GA, USA.
Patrick F KiserDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Betsy C HeroldDepartment of Pediatrics and Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
James M SmithCenters for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USNorthwestern University · USAlbert Einstein College of Medicine · USTotal (France) · FR

Funding

Pharmacokinetics and Biodistribution of Antiretrovirals and HIV-1 in MacaquesU19AI103461 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MITCHNICK, MARK · 2013 to 2017
$13.2M
Intramural CDC HHS CC999999NIAID NIH HHS U19 AI103461
6 · The paper itself

Abstract

backgroundIntravaginal rings (IVR) for HIV prevention will likely be used by women on depot medroxyprogesterone acetate (DMPA) hormonal contraception. We used pigtailed macaques to evaluate the effects of DMPA on tenofovir disoproxil fumarate (TDF) IVR pharmacokinetics and viral shedding.

methodsMucosal tenofovir (TFV) levels were compared in SHIV

resultsSimilar median vaginal fluid TFV concentrations were observed in the DMPA-treated and cycling macaques over 4 weeks (1.2×10

conclusionsDMPA does not affect TDF IVR pharmacokinetics or SHIV shedding.

Indexed as

Administration, IntravaginalAnimalsAnti-HIV AgentsContraceptive Agents, FemaleContraceptive Devices, FemaleFemaleHIVHIV InfectionsMacaca nemestrinaMedroxyprogesterone AcetateTenofovirViremiaVirus SheddingAnti-HIV AgentsContraceptive Agents, FemaleMedroxyprogesterone AcetateTenofovirDMPA and HIVmucosal HIV sheddingnonhuman primatesSHIVtenofovir pharmacokinetics

Identifiers

PMID28748662
PMCPMC7192064
OpenAlexW2740824381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.