Evidence map›Paper›PMID 28748627›Full record

ArticleActa physiologica (Oxford, England)2018

Genetic ablation of carbonic anhydrase IX disrupts gastric barrier function via claudin-18 downregulation and acid backflux.

T Li, X Liu, B Riederer, K Nikolovska, A K Singh, K A Mäkelä, A Seidler, Y Liu, G Gros, H Bartels and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis.Digestive diseases and sciences · 2022
    Article
  9. Article
  10. Review
  11. Carbonic Anhydrase IX-Mouse versus Human.International journal of molecular sciences · 2019
    Article
  12. Article
  13. Gastroduodenal Injury: Role of Protective Factors.Current gastroenterology reports · 2019
    Review
  14. Review
  15. Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma.Virchows Archiv : an international journal of pathology · 2018
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

T LiDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
X LiuDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
B RiedererDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
K NikolovskaDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
A K SinghDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
K A MäkeläInstitute of Biomedicine and Biocenter of Oulu, Oulu University, Finland.
A SeidlerDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
Y LiuDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
G GrosDepartment of Physiology, Hannover Medical School, Hannover, Germany.
H BartelsDepartment of Anatomy, Hannover Medical School, Hannover, Germany.
K H HerzigInstitute of Biomedicine and Biocenter of Oulu, Oulu University, Finland.
U SeidlerDepartment of Gastroenterology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEBiocenter Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to explore the molecular mechanisms for the parietal cell loss and fundic hyperplasia observed in gastric mucosa of mice lacking the carbonic anhydrase 9 (CAIX).

methodsWe assessed the ability of CAIX-knockout and WT gastric surface epithelial cells to withstand a luminal acid load by measuring the pH

resultsCAIX-knockout gastric surface epithelial cells showed significantly faster pH

conclusionsWe propose that CAIX converts protons that either backflux or are extruded from the cells rapidly to CO

Indexed as

AnimalsCarbonic Anhydrase IXClaudinsDown-RegulationGastric AcidGastric MucosaHydrogen-Ion ConcentrationMiceMice, Inbred C57BLMice, KnockoutParietal Cells, GastricCar9 protein, mouseCarbonic Anhydrase IXClaudinsCldn18 protein, mousecarbonic anhydraseclaudinsgastric acidgastric mucosal defencepHi regulationtight junctions

Identifiers

PMID28748627
PMCPMC5901031
OpenAlexW2741619989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.