ArticleSmall (Weinheim an der Bergstrasse, Germany)2017
Photoacoustic-Guided Surgery with Indocyanine Green-Coated Superparamagnetic Iron Oxide Nanoparticle Clusters.
Article in Small (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Nanophotonic-enhanced photoacoustic imaging for brain tumor detection.Journal of nanobiotechnology · 2025Review
- Article
- Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors.Nanotheranostics · 2024Article
- Hemin-Coated Nanoparticles as Drug Delivery Vehicles for Chemotherapeutic Agents in Cancer Therapy.ACS applied nano materials · 2023Article
- Phthalocyanine-Blue Nanoparticles for the Direct Visualization of Tumors with White Light Illumination.ACS applied materials & interfaces · 2023Article
- Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: "Always-On" and "Turn-On" Probes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Dual-wavelength photoacoustic atlas method to estimate fractional methylene blue and hemoglobin contents.Journal of biomedical optics · 2022Article
- Polymeric magnetic nanoparticles: a multitargeting approach for brain tumour therapy and imaging.Drug delivery and translational research · 2022Review
- Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma.Journal of nanobiotechnology · 2022Review
- Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging.Bioactive materials · 2022Review
- Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics.Materials today. Bio · 2022Article
- Bacteria Wear ICG Clothes for Rapid Detection of Intracranial Infection in Patients After Neurosurgery and Photothermal Antibacterial Therapy AgainstFrontiers in bioengineering and biotechnology · 2022Article
- Advances in magnetic resonance imaging contrast agents for glioblastoma-targeting theranostics.Regenerative biomaterials · 2021Review
- Nanotechnology for Cancer Imaging: Advances, Challenges, and Clinical Opportunities.Radiology. Imaging cancer · 2021Review
- Photoacoustic-guided surgery from head to toe [Invited].Biomedical optics express · 2021Review
- Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster.Journal of neuro-oncology · 2020Article
- Photoacoustic imaging for surgical guidance: Principles, applications, and outlook.Journal of applied physics · 2020Article
- Image-guided tumor surgery: The emerging role of nanotechnology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- High-Resolution Photoacoustic Tomography for Early-Stage Cancer Detection and Its Clinical Translation.Radiology. Imaging cancer · 2020Review
- Indocyanine Green-Coated Polycaprolactone Micelles for Fluorescence Imaging of Tumors.ACS applied bio materials · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A common cause of local tumor recurrence in brain tumor surgery results from incomplete surgical resection. Adjunctive technologies meant to facilitate gross total resection have had limited efficacy to date. Contrast agents used to delineate tumors preoperatively cannot be easily or accurately used in the real-time operative setting. Although multimodal imaging contrast agents are developed to help the surgeon discern tumor from normal tissue in the operating room, these contrast agents are not readily translatable. This study has developed a novel contrast agent comprised solely of two Food and Drug Administration approved components, indocyanine green (ICG) and superparamagnetic iron oxide (SPIO) nanoparticles-with no additional amphiphiles or carrier materials, to enable preoperative detection by magnetic resonance (MR) imaging and intraoperative photoacoustic (PA) imaging. The encapsulation efficiency of both ICG and SPIO within the formulated clusters is ≈100%, and the total ICG payload is 20-30% of the total weight (ICG + SPIO). The ICG-SPIO clusters are stable in physiologic conditions; can be taken up within tumors by enhanced permeability and retention; and are detectable by MR. In a preclinical surgical resection model in mice, following injection of ICG-SPIO clusters, animals undergoing PA-guided surgery demonstrate increased progression-free survival compared to animals undergoing microscopic surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.