Evidence map›Paper›PMID 28748596›Full record

ReviewStem cells (Dayton, Ohio)2017

Concise Review: Stem Cells for Corneal Wound Healing.

Mehrnoosh Saghizadeh, Andrei A Kramerov, Clive N Svendsen, Alexander V Ljubimov

Abstract readReview
In one paragraph

Review in Stem cells (Dayton, Ohio), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Multiple Stem/Progenitor Cells Isolated from the Limbus.Current stem cell research & therapy · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Corneal Epithelial Regeneration: Old and New Perspectives.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mehrnoosh SaghizadehCedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.
Andrei A KramerovCedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.
Clive N SvendsenCedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.
Alexander V LjubimovCedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.ORCID 0000-0003-2398-5319

Funding

Mechanisms of Epithelial Alterations in Diabetic CorneaR01EY013431 · NEI · CEDARS-SINAI MEDICAL CENTER · PI Alexander V Ljubimov · 2001 to 2026
$11.3M
The Role of MicroRNAs in Normal and Diseased Corneal Epithelial HomeostasisR01EY025377 · NEI · CEDARS-SINAI MEDICAL CENTER · PI Mehrnoosh Saghizadeh Ghiam · 2015 to 2026
$4.3M
Regulation of Limbal Niche in Normal and Diabetic Cornea by Extracellular VesiclesR01EY029829 · NEI · CEDARS-SINAI MEDICAL CENTER · PI GHIAM, MEHRNOOSH SAGHIZADEH · 2019 to 2023
$2.6M
Wnt5a, a New Diabetic Corneal Marker Related to Wound HealingR01EY031377 · NEI · CEDARS-SINAI MEDICAL CENTER · PI LJUBIMOV, ALEXANDER V · 2020 to 2024
$2.1M
Transplantable limbal cells from induced pluripotent stem cellsR01EY023429 · NEI · CEDARS-SINAI MEDICAL CENTER · PI LJUBIMOV, ALEXANDER V · 2013 to 2015
$1.2M
NEI NIH HHS R01 EY013431NEI NIH HHS R01 EY023429NEI NIH HHS R01 EY025377NEI NIH HHS R01 EY029829NEI NIH HHS R01 EY031377
6 · The paper itself

Abstract

Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of stromal and endothelial progenitors is less well studied. The available evidence on stem cell participation in corneal wound healing is reviewed, together with the data on the use of corneal and non-corneal stem cells to facilitate this process in diseased or postsurgical conditions. Important aspects of corneal stem cell generation from alternative cell sources, including pluripotent stem cells, for possible transplantation upon corneal injuries or in disease conditions are also presented. Stem Cells 2017;35:2105-2114.

Indexed as

HumansStem CellsWound HealingCell transplantationCorneal endotheliumCorneal epitheliumGene therapyKeratocytePluripotent stem cellStem cellWound healing

Identifiers

PMID28748596
PMCPMC5637932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.