Evidence map›Paper›PMID 28748562›Full record

ArticleMagnetic resonance in medicine2018

Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging.

Aman Khurana, Fanny Chapelin, Hongyan Xu, Joseph R Acevedo, Alfred Molinolo, Quyen Nguyen, Eric T Ahrens

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018
    Trial
  2. Article
  3. Review
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  5. Review
  6. Spatio-Temporal Dynamics of MBulletin of mathematical biology · 2025
    Article
  7. Journal of magnetic resonance imaging : JMRI · 2025
    Article
  8. Article
  9. Article
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  11. Review
  12. Article
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  14. Article
  15. Review
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  17. Re-engineered imaging agent using biomimetic approaches.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  18. Review
  19. Article
  20. Metallofluorocarbon Nanoemulsion for Inflammatory Macrophage Detection via PET and MRI.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aman KhuranaDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Fanny ChapelinDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
Hongyan XuDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Joseph R AcevedoSchool of Medicine, University of California San Diego, La Jolla, California, USA.
Alfred MolinoloDepartment of Pathology, University of California San Diego, La Jolla, California, USA.
Quyen NguyenDepartment of Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.
Eric T AhrensDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USLa Jolla Bioengineering Institute · US

Funding

CLINICAL TRANSLATION OF 19F MRI TO VISUALIZE CANCER IMMUNOTHERAPEUTIC CELLSR01CA134633 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T., COHEN, EZRA · 2009 to 2021
$4.4M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
Compositions and methods for enhanced fluorine-19 magnetic resonance imaging cell trackingR01EB024015 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T. · 2017 to 2020
$2.3M
Intracellular oxygen sensing using 19F MRIR01EB017271 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AHRENS, ERIC T. · 2013 to 2016
$1.3M
NCATS NIH HHS TL1 TR001443NCI NIH HHS R01 CA134633NIBIB NIH HHS R01 EB017271NIBIB NIH HHS R01 EB024015
6 · The paper itself

Abstract

purposeTo evaluate the role of infiltrating macrophages in murine models of single and double mutation head and neck tumors using a novel fluorine-19 (

methodsTumor cell lines single-hit/SCC4 or double-hit/Cal27, with mutations of TP53 and TP53 & FHIT, respectively, were injected bilaterally into the flanks of (n = 10) female mice. With tumors established, perfluorocarbon nanoemulsion was injected intravenously, which labels in situ predominantly monocytes and macrophages. Longitudinal spin density-weighted

resultsThe average number of

conclusionsThis study helps to establish

Indexed as

Fluorine-19 Magnetic Resonance ImagingAnimalsCarcinomaCell Line, TumorFemaleFluorineHead and Neck NeoplasmsHumansInflammationMacrophagesMiceMice, NudeMice, TransgenicMutationTongue NeoplasmsTumor MicroenvironmentFluorinefluorine-19head and neck cancerinflammationMRIperfluorocarbon

Identifiers

PMID28748562
PMCPMC5807236
OpenAlexW2738454556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.