ArticleThe international journal of cardiovascular imaging2018
Left ventricular function in patients with hypertrophic cardiomyopathy and its relation to myocardial fibrosis and exercise tolerance.
Article in The international journal of cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of exercise for hypertrophic cardiomyopathy: a systematic review and meta-analysis.Proceedings (Baylor University. Medical Center) · 2026Pooled it
- Quantitative assessment of early changes in myocardial extracellular volume during postoperative adjuvant chemotherapy in patients with breast cancer via dual-layer spectral detector computed tomography: a cohort study.Quantitative imaging in medicine and surgery · 2025Article
- Rediscovering the value of exercise in patients with hypertrophic cardiomyopathy.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- Exercise Recommendations in Pediatric HCM: Variation and Influence of Provider Characteristics.Pediatric cardiology · 2022Article
- Treatment of myocardial interstitial fibrosis in pathological myocardial hypertrophy.Frontiers in pharmacology · 2022Review
- Fibrosis in hypertrophic cardiomyopathy: role of novel echo techniques and multi-modality imaging assessment.Heart failure reviews · 2021Review
- Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Prognostic value of myocardial extracellular volume fraction evaluation based on cardiac magnetic resonance T1 mapping with T1 long and short in hypertrophic cardiomyopathy.European radiology · 2021Article
- Associations of Social Vulnerability Index With Pathologic Myocardial Findings at Autopsy.Frontiers in cardiovascular medicine · 2021Article
- Hemodynamic determinants of left atrial strain in patients with hypertrophic cardiomyopathy: A combined echocardiography and CMR study.PloS one · 2021Article
- Brazilian Cardiovascular Rehabilitation Guideline - 2020.Arquivos brasileiros de cardiologia · 2020Article
- Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4: JACC Focus Seminar.Journal of the American College of Cardiology · 2020Review
- Role of the Extracellular Matrix in the Pathogenesis of Hypertrophic Cardiomyopathy.JACC. Basic to translational science · 2019Article
- Mechanisms of cardiac collagen deposition in experimental models and human disease.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Cardiovascular imaging 2018 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to determine the relation between myocardial extracellular volume (ECV), left ventricular (LV) diastolic function, and exercise tolerance in patients with hypertrophic cardiomyopathy (HCM). Forty five HCM patients with an ejection fraction >50% and no previous septal reduction therapy underwent imaging by CMR and transthoracic echocardiography. CMR was used to quantify LV volumes, mass, EF, LA volumes, scar burden, pre and post contrast T1 relaxation times and ECV. Echocardiography was used to measure outflow tract gradients, mitral inflow and annular velocities, circumferential strain, systolic, early and late diastolic strain rates. Exercise duration and peak oxygen consumption were noted. HCM patients had increased native T1 relaxation time and ECV vs. controls [ECV controls: 24.7 (23.2-26.4) vs. HCM: 26.8 (24.6-31.3)%, P = 0.014]. Both parameters were significantly associated with LV diastolic dysfunction, circumferential strain, diastolic strain rate and peak oxygen consumption (r = -0.73, P < 0.001). Compared to controls, HCM patients have significantly longer native T1 relaxation time and higher ECV. These structural changes lead to worse LV global and segmental diastolic function and in turn reduced exercise tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.