Evidence map›Paper›PMID 28748387›Full record

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Costs of fragility hip fractures globally: a systematic review and meta-regression analysis.

S Williamson, F Landeiro, T McConnell, L Fulford-Smith, M K Javaid, A Judge, J Leal

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07027241 (Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients), which is not on this map. Cited by 151 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07027241 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients

TypeinterventionalSponsorRoyal College of Surgeons, IrelandRan2025 to 2026Enrolled50ConditionsHip Fractures (ICD-10 72.01-72.2), Frailty at Older Adults, Strength Training, Resistance TrainingArmsExercise Intervention, Usual Care, Nutritional Intervention
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  12. Arthroplasties for hip fracture in adults.The Cochrane database of systematic reviews · 2022
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  16. Internal fixation implants for intracapsular hip fractures in older adults.The Cochrane database of systematic reviews · 2021
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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S WilliamsonHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
F LandeiroHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
T McConnellHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
L Fulford-SmithHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
M K JavaidOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
A JudgeOxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
J LealHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Jose.leal@dph.ox.ac.uk.

Funding

Department of Health 11/1023/01
6 · The paper itself

Abstract

Purpose This study was conducted in order to systematically review the costs of hip fractures globally and identify drivers of differences in costs. Methods A systematic review was conducted to identify studies reporting patient level fragility hip fracture costs between 1990 and 2015. We extracted data on the participants and costs from these studies. Cost data concerning the index hospitalisation were pooled, and a meta-regression was used to examine its potential drivers. We also pooled data on the first-year costs following hip fracture and considered healthcare, social care as well as other cost categories if reported by studies. Results One hundred and thirteen studies reported costs of hip fracture based on patient level data. Patients developing complications as well as patients enrolled in intervention arms of comparative studies were found to have significantly higher costs compared to the controls. The pooled estimate of the cost for the index hospitalisation was $10,075. Health and social care costs at 12 months were $43,669 with inpatient costs being their major driver. Meta-regression analysis identified age, gender and geographic region as being significantly associated with the differences in costs for the index hospitalisation. Conclusion Hip fracture poses a significant economic burden and variation exists in their costs across different regions. We found that there was a considerable variation across studies in terms of study design, methodology, follow-up period, costs considered and results reported that highlights the need for more standardisation in this area of research.

Indexed as

Fracture FixationHealth Care CostsHealth Services ResearchHip FracturesHospitalizationHumansOsteoporotic FracturesCostsHip fractureMeta-regressionSystematic review

Identifiers

PMID28748387

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.