Evidence map›Paper›PMID 28748372›Full record

ArticleEuropean journal of applied physiology2017

Training and acute exercise modulates mitochondrial dynamics in football players' blood mononuclear cells.

Carla Busquets-Cortés, Xavier Capó, Miquel Martorell, Josep A Tur, Antoni Sureda, Antoni Pons

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Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

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  8. Journal of clinical biochemistry and nutrition · 2021
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  15. Mitochondrial dynamics in exercise physiology.Pflugers Archiv : European journal of physiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Carla Busquets-CortésResearch Group on Community Nutrition and Oxidative Stress, Science Laboratory of Physical Activity, Department of Fundamental Biology and Health Sciences, University of Balearic Islands, 07122, Palma de Mallorca, Spain.
Xavier CapóResearch Group on Community Nutrition and Oxidative Stress, Science Laboratory of Physical Activity, Department of Fundamental Biology and Health Sciences, University of Balearic Islands, 07122, Palma de Mallorca, Spain.
Miquel MartorellDepartamento de Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, Chile, 4070386, Concepción, Chile.
Josep A TurResearch Group on Community Nutrition and Oxidative Stress, Science Laboratory of Physical Activity, Department of Fundamental Biology and Health Sciences, University of Balearic Islands, 07122, Palma de Mallorca, Spain.
Antoni SuredaResearch Group on Community Nutrition and Oxidative Stress, Science Laboratory of Physical Activity, Department of Fundamental Biology and Health Sciences, University of Balearic Islands, 07122, Palma de Mallorca, Spain.
Antoni PonsResearch Group on Community Nutrition and Oxidative Stress, Science Laboratory of Physical Activity, Department of Fundamental Biology and Health Sciences, University of Balearic Islands, 07122, Palma de Mallorca, Spain. antonipons@uib.es.
Instituto de Salud Carlos III · ESUniversitat de les Illes Balears · ESUniversity of Concepción · CL

Funding

Acción Estratégica en Salud del Ministerio de Ciencia e Innovación DPS2008-07033-C03-03Balearic Island Government and FEDER funds 23/2012Balearic Island Government and FEDER funds 35/2011by Conselleria d'Educació, Cultura i Universitats, Direcció General d'Universitats i Recerca, Govern de les Illes Balears. FPI/1648/2014Programme of Promotion of Biomedical Research and Health Sciences PI11/01791Programme of Promotion of Biomedical Research and Health Sciences PI14/00636Red Predimed-RETIC RD06/0045/1004
6 · The paper itself

Abstract

purposeRegular physical activity induces oxidative stress but also causes adaptations in antioxidant defences including the nuclear factor κB (NF-κB) pathway, which activates target genes related to antioxidant defences such as uncoupling proteins (UCPs), and mitochondrial biogenesis mediated by peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). The aim of the study was to determine the effect of long-term training and acute exercise on oxidant/antioxidant status and the expression of mitochondrial biogenesis genes in peripheral blood mononuclear cells (PBMCs).

methodsTwelve professional football players performed an 8-week exercise programme comprising a daily 2-h football training session. Blood samples were taken before and after the training season.

resultsThe results reported a significant increase in antioxidant protein levels and in mitochondrial proteins in resting conditions after the 8-week training period. PGC1α, UCP-2 and mitofusin 2 protein levels also increased after acute exercise compared to pre-exercise levels. After the training, the expression of PGC1α, cytochrome c oxidase subunit IV and mitochondrial NADH dehydrogenase subunit 5 messenger RNA (mRNA) significantly augmented after the acute physical activity compared to pre-exercise levels; while no changes occurred in these mRNA in basal conditions. NF-κB activation and ROS production reported a significant increase after acute exercise.

conclusionsTraining increases the levels of proteins related to mitochondrial biogenesis and improves the antioxidant capabilities of mitochondria in PBMCs among well-trained football players. Acute exercise may act as an inducer of mitochondrial biogenesis through NF-κB activation and PGC1α gene expression.

Indexed as

High-Intensity Interval TrainingMitochondrial DynamicsOxidative StressElectron Transport Complex IVFootballGTP PhosphohydrolasesHumansMaleMitochondrial ProteinsMonocytesNADH DehydrogenasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaUncoupling Protein 2Young AdultElectron Transport Complex IVGTP PhosphohydrolasesMFN2 protein, humanMitochondrial ProteinsNADH DehydrogenasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanUCP2 protein, humanUncoupling Protein 2BiogenesisFissionFusionMitochondriaPBMCsTraining

Identifiers

PMID28748372
OpenAlexW2738617048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.