Evidence map›Paper›PMID 28748335›Full record

ArticleJournal of autism and developmental disorders2017

The Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder.

Eric Rubenstein, Rebecca Edmondson Pretzel, Gayle C Windham, Laura A Schieve, Lisa D Wiggins, Carolyn DiGuiseppi, Andrew F Olshan, Annie G Howard, Brian W Pence, Lisa Young and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Eric RubensteinDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, 135 Dauer Dr, Chapel Hill, NC, 27599, USA. erubens@live.unc.edu.ORCID http://orcid.org/0000-0002-9146-4497
Rebecca Edmondson PretzelUniversity of North Carolina at Chapel Hill Center for Intellectual and Developmental Disabilities, 101 Renee Lynne Ct, Carrboro, NC, 27510, USA.
Gayle C WindhamDivision of Environmental and Occupational Disease Control, California Department of Public Health, 850 Marina Bay Pkwy, Bldg. P, Richmond, CA, 94804, USA.
Laura A SchieveCenters for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, 1600 Clifton Road, Atlanta, GA, 30329, USA.
Lisa D WigginsCenters for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, 1600 Clifton Road, Atlanta, GA, 30329, USA.
Carolyn DiGuiseppiDepartment of Epidemiology, Colorado School of Public Health, Campus Box B119, 13001 E. 17th Place, Aurora, CO, 80045, USA.
Andrew F OlshanDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.
Annie G HowardDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, 137 East Franklin Street Room 6702 CB# 8030, Chapel Hill, NC, 27514, USA.
Brian W PenceDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.
Lisa YoungUniversity of Pennsylvania School of Nursing, 420 Guardian Drive, Philadelphia, PA, 19104, USA.
Julie DanielsDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, 135 Dauer Dr, Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill · USCenters for Disease Control and Prevention · USCalifornia Department of Public Health · USColorado School of Public Health · USUniversity of Pennsylvania · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort StudyU10DD000183 · DD · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2006 to 2010
$8.2M
MD CADDRE: Study to Explore Early Development, SEED Phase IIU01DD000746 · DD · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2011 to 2015
$7.0M
Component A: NC Study to Explore Early Development Phase 3 (SEED 3)U01DD001205 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2016 to 2020
$6.4M
National CADDRE Study: Child Development and AutismU10DD000182 · DD · UNIVERSITY OF PENNSYLVANIA · PI PINTO-MARTIN, JENNIFER A · 2006 to 2010
$5.8M
National CADDRE Study: Child Development and AutismU10DD000181 · DD · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2006 to 2010
$5.6M
Colorado CADDRE: A Case-Cohort StudyU10DD000180 · DD · COLORADO STATE DEPT/PUB HLTH & ENVIRONMT · PI MILLER, LISA ANN · 2006 to 2010
$5.1M
North Carolina Ctr for Autism & Development Disabilities Research & EpidemiologyU10DD000184 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2006 to 2010
$4.7M
Component A: CADDRE: Study to Explore Early Development (SEED) 3U01DD001210 · DD · UNIVERSITY OF COLORADO DENVER · PI ROBINSON, CORDELIA · 2016 to 2020
$3.8M
Data Coordinating Center for Autism & Other DisabilitiesU01DD000498 · DD · MICHIGAN STATE UNIVERSITY · PI REED, PHILIP L · 2009 to 2011
$2.3M
Autism Speaks 10052CDC HHS Cooperative Agreement Number U10DD000180, Colorado Department of Public Health; Cooperative Agreement Number U10DD000181, Kaiser Foundation Research Institute (CA); Cooperative Agreement Number U10DD000182, University of Pennsylvania; Cooperative Agreement Number U10DD000183, Johns Hopkins University; Cooperative Agreement Number U10DD000184, University of North Carolina at Chapel Hill; and Cooperative Agreement Number U10DD000498, Michigan State UniversityNCBDD CDC HHS U01 DD000498NCBDD CDC HHS U01 DD000746NCBDD CDC HHS U01 DD001205NCBDD CDC HHS U01 DD001210NCBDD CDC HHS U10 DD000180NCBDD CDC HHS U10 DD000181NCBDD CDC HHS U10 DD000182NCBDD CDC HHS U10 DD000183NCBDD CDC HHS U10 DD000184NICHD NIH HHS P2C HD050924NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to 'over-' or 'under-report' child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD.

Indexed as

PhenotypeAdultAutism Spectrum DisorderCase-Control StudiesChildChild, PreschoolDevelopmental DisabilitiesFemaleHumansMaleMothersPhysician's RoleAutism Diagnostic Interview-RevisedAutism Diagnostic Observation ScheduleAutism spectrum disorderBroader autism phenotypeInstrument discordance

Identifiers

PMID28748335
PMCPMC5728366
OpenAlexW2738084746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.