Evidence map›Paper›PMID 28748334›Full record

Trial reportJournal of autism and developmental disorders2017

Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms.

Kelly W Sheppard, Kelly M Boone, Barbara Gracious, Mark A Klebanoff, Lynette K Rogers, Joseph Rausch, Christopher Bartlett, Daniel L Coury, Sarah A Keim

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Nutraceuticals in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Effects ofNutrients · 2019
    Trial
  7. Trial
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Speech-Stimulating Substances in Autism Spectrum Disorders.Behavioral sciences (Basel, Switzerland) · 2019
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kelly W SheppardCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA. kelly.sheppard@nationwidechildrens.org.
Kelly M BooneCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Barbara GraciousCenter for Innovation in Pediatric Practice, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Mark A KlebanoffCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Lynette K RogersCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Joseph RauschCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Christopher BartlettBattelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Daniel L CouryCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Sarah A KeimCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.
Nationwide Children's Hospital · USThe Ohio State University · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
NCATS NIH HHS UL1 TR001070NCATS NIH HHS UL1TR001070
6 · The paper itself

Abstract

Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD.

Indexed as

Language DevelopmentAutism Spectrum DisorderChildChild, PreschoolDietary SupplementsFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansInfantInfant, NewbornInfant, PrematureMaleFatty Acids, Omega-3Fatty Acids, Omega-6Autism spectrum disorderChildren born pretermLanguage developmentMacArthur Bates communicative development inventoryOmega-3 fatty acidsOmega-6 fatty acids

Identifiers

PMID28748334
PMCPMC9540981
OpenAlexW2737239219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.