Evidence map›Paper›PMID 28748309›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2017

Interaction of Zn(II)bleomycin-A

Shelby E Follett, Azure D Ingersoll, Sally A Murray, Teresa M Reilly, Teresa E Lehmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. [Development of precancerous lesions of oral mucous membrane diseases and oral cancer animal models].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shelby E FollettDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Azure D IngersollDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Sally A MurrayDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Teresa M ReillyDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA.
Teresa E LehmannDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY, 82071, USA. tlehmann@uwyo.edu.
University of Wyoming · US

Funding

Role of the bleomycin C-termini in DNA binding and toxicity by metallo-bleomycinsR15GM106285 · NIGMS · UNIVERSITY OF WYOMING · PI LEHMANN, TERESA E · 2014 to 2014
$298k
National Institute of Health R15GM106258NIGMS NIH HHS R15 GM106285
6 · The paper itself

Abstract

Bleomycins are a group of glycopeptide antibiotics synthesized by Streptomyces verticillus that are widely used for the treatment of various neoplastic diseases. These antibiotics have the ability to chelate a metal center, mainly Fe(II), and cause site-specific DNA cleavage. Bleomycins are differentiated by their C-terminal regions. Although this antibiotic family is a successful course of treatment for some types of cancers, it is known to cause pulmonary fibrosis. Previous studies have identified that bleomycin-related pulmonary toxicity is linked to the C-terminal region of these drugs. This region has been shown to closely interact with DNA. We examined the binding of Zn(II)peplomycin and Zn(II)bleomycin-A

Indexed as

Antibiotics, AntineoplasticBinding SitesBleomycinDNAHumansNeoplasmsNuclear Magnetic Resonance, BiomolecularPeplomycinZincAntibiotics, AntineoplasticBleomycinDNAPeplomycinZincAnticancer drugDNANMRPulmonary fibrosisStructure–function

Identifiers

PMID28748309
PMCPMC5985968
OpenAlexW2736605781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.