Evidence map›Paper›PMID 28748218›Full record

ArticleCancer translational medicine2017

Autophagy regulated by miRNAs in colorectal cancer progression and resistance.

Andrew Fesler, Hua Liu, Ning Wu, Fei Liu, Peixue Ling, Jingfang Ju

Open access · greenAbstract read
In one paragraph

Article in Cancer translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Autophagy Paradox of Cancer: Role, Regulation, and Duality.Oxidative medicine and cellular longevity · 2021
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Andrew FeslerDepartment of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.
Hua LiuDepartment of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.
Ning WuDepartment of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.
Fei LiuShandong Academy of Pharmaceutical Sciences, Jinan, 250101, P. R. China.
Peixue LingShandong Academy of Pharmaceutical Sciences, Jinan, 250101, P. R. China.
Jingfang JuDepartment of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.
Shandong Academy of Pharmaceutical Sciences · CNChinese Academy of Sciences · CNStony Brook University · US

Funding

Roles of miR-129 in colorecal cancerR01CA197098 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI JU, JINGFANG · 2016 to 2020
$1.8M
Molecular Mechanism of miR-140 in Colon CancerR01CA155019 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI JU, JINGFANG · 2011 to 2014
$1.5M
NCI NIH HHS R01 CA155019NCI NIH HHS R01 CA197098
6 · The paper itself

Abstract

The catabolic process of autophagy is an essential cellular function that allows for the breakdown and recycling of cellular macromolecules. In recent years, the impact of epigenetic regulation of autophagy by non-coding microRNAs (miRNAs) has been recognized in human cancer. In colorectal cancer, Autophagy plays critical roles in cancer progression as well as resistance to chemotherapy, and recent evidence demonstrates that miRNAs are directly involved in mediating these functions. In this review, we will focus on the recent advancements in the field of miRNA regulation of autophagy in colorectal cancer.

Indexed as

Autophagycancer stem cellchemotherapycolorectal cancermicroRNA

Identifiers

PMID28748218
PMCPMC5524452
OpenAlexW2622580625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.