Evidence map›Paper›PMID 28748216›Full record

ArticleJournal of nature and science2017

T cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury.

Andrés Cruz-Herranz, Sharon A Sagan, Raymond A Sobel, Ari J Green, Scott S Zamvil

Open access · greenAbstract readComment
PubMed Full text at PMC
In one paragraph

Article in Journal of nature and science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. New Therapeutic Landscape in Neuromyelitis Optica.Current treatment options in neurology · 2021
    Review
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrés Cruz-HerranzDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
Sharon A SaganDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
Raymond A SobelDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Ari J GreenDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
Scott S ZamvilDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
University of California, San Francisco · USStanford University · US

Funding

B cells in CNS autoimmunityR01AI073737 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2009 to 2013
$1.9M
Disease relevance of CD20 expression on T cells in multiple sclerosis patientsR01NS092835 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2015 to 2018
$1.7M
Regulatory monocytes in CNS autoimmune diseaseR01NS063008 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2009 to 2013
$1.3M
NIAID NIH HHS R01 AI073737NINDS NIH HHS R01 NS063008NINDS NIH HHS R01 NS092835
6 · The paper itself

Abstract

Aquaporin-4 (AQP4)-specific antibodies are instrumental in promoting central nervous system (CNS) tissue injury in neuromyelitis optica (NMO), yet evidence indicates that AQP4-specific T cells also have a pivotal role in NMO pathogenesis. Although considerable effort has been devoted to creation of animal models to study how AQP4-specific T cells and antibodies may cooperate in development of both clinical and histologic opticospinal inflammatory disease, the initial attempts were unsuccessful. Recently, it was discovered that T cells from AQP4-deficient (AQP4

Indexed as

aquaporin-4experimental autoimmune encephalomyelitisexperimental neuromyelitis opticaneuromyelitis opticaT cells

Identifiers

PMID28748216
PMCPMC5523104
OpenAlexW2621351195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.