ArticleAvicenna journal of phytomedicine
Stereological investigation of the effect of
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg.European journal of nutrition · 2024Article
- Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats.Frontiers in pharmacology · 2024Article
- Hydroalcoholic extract ofHeliyon · 2023Article
- Lycopene prevents bone loss in ovariectomized rats and increases the number of osteocytes and osteoblasts.Journal of anatomy · 2022Article
- The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat.BMC complementary medicine and therapies · 2022Article
- Comparing the effects of Elaegnus Angustifolia, Hypericum Perforatum and Psidium Guajava extracts on metabolic activity of dental pulp-derived mesenchymal stem cells.Cell and tissue banking · 2022Article
- Investigating the Effect of Hydroalcoholic Extract of Licorice Root to Prevent Ovariectomy-Mediated Complications.BioMed research international · 2022Article
- Exploring the bone sparing effects of postbiotics in the post-menopausal rat model.BMC complementary medicine and therapies · 2021Article
- Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats.Veterinary medicine and science · 2021Article
- Phytocomplex Characterization and Biological Evaluation of Powdered Fruits and Leaves fromMolecules (Basel, Switzerland) · 2020Article
- Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss.Probiotics and antimicrobial proteins · 2019Article
- The Effects of Soy Milk Enriched with Lactobacillus casei and Omega-3 on the Tibia and L5 Vertebra in Diabetic Rats: a Stereological Study.Probiotics and antimicrobial proteins · 2019Article
- Diosgenin protects against alveolar bone loss in ovariectomized rats via regulating long non-coding RNAs.Experimental and therapeutic medicine · 2018Article
- Effects of the Hydroalcoholic Extract of theIranian journal of medical sciences · 2018Article
- [Estradiol significantly increases the expression of antioxidant enzymes in osteoporotic rats and osteoblasts in vitro].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Protective effect of the olive hydroalcoholic extract on estrogen deficiency-induced bone loss in rats in comparison with estradiol.Avicenna journal of phytomedicineArticle
- Protective effects ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePostmenopausal osteoporosis is characterized by increased fracture risk. However, each approved treatment has specific side effects. Therefore, foods with plant origins have increasingly attracted attention as an alternative treatment. Studies have shown that MATERIAL AND
methods55 female Sprague-Dawley rats were randomly assigned to control, sham operated (normal saline), ovariectomized (OVX), OVX + EA fruit extract (600 mg/kg BW/day), and OVX + estradiol benzoate (3 mg/kg BW) for 16 weeks. Blood samples were collected to measure calcium, phosphorus, and alkaline phosphatase (ALP) plasma levels. Then, specimens from tibia and fifth lumbar vertebra (L5) bones were prepared and stereological analysis was done.
resultsOvariectomy significantly decreased the calcium level and increased the ALP level in the OVX group. In spite of improvement in calcium hemostasis in groups treated with estrogen and EA fruit extract (p<0.05), only treatment with estrogen was able to reduce ALP levels. Moreover, treatment with EA fruit extract and estrogen caused a significant increase in the number of osteoblasts in vertebra and tibia compared to the OVX group (p<0.05). Estrogen and EA fruit extract were also able to reduce the number of osteoclasts in tibia of the treated OVX rats (p<0.05).
conclusionThe results showed that EA extract exerted more effects, markedly, on osteoblastogenesis in the OVX rats. Thus, it could be considered as a potential agent to treat patients with osteoporosis.
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Identifiers
28748173PMC5511978W2593636100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.