ReviewJournal of advanced research2017
Serum uric acid and acute kidney injury: A mini review.
Review in Journal of advanced research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Jet Fuel Effects on Hepatic and Renal Health: A Fit-for-Purpose Systematic Literature Review.Journal of occupational and environmental medicine · 2026Pooled it
- Role and mechanisms of SGLT-2 inhibitors in the treatment of diabetic kidney disease.Frontiers in immunology · 2023Pooled it
- Renoprotective effect of febuxostat on contrast-induced acute kidney injury in chronic kidney disease patients stage 3: randomized controlled trial.BMC nephrology · 2023Trial
- Multisystem Complications in Non-Transfusion-Dependent β-Thalassemia Intermedia: A Case Highlighting the Need for Early Intervention.Clinical case reports · 2026Article
- Phosphate: An Anion Controlling Metabolic Functions.Nutrients · 2026Review
- Associations between cholesterol, high-density lipoprotein, and glucose index and hyperuricemia in patients with diabetes.BMC endocrine disorders · 2026Article
- Heat Stress and Kidney Injury: A Growing Concern Amidst Climate Change.Kidney medicine · 2026Review
- Risk factors and a nomogram for predicting severe acute kidney injury in pediatric sepsis: a retrospective study.Frontiers in pediatrics · 2026Article
- Ameliorating Acute Kidney Injury Induced by Ischemia-Reperfusion by Targeting Purine Metabolism.International journal of molecular sciences · 2025Article
- Biomarkers of Kidney Function and Injury Across Fire Seasons and During a Mid-Season Fire Incident in the Wildland Firefighter Exposure and Health Effect (WFFEHE) Study.American journal of industrial medicine · 2025Article
- Trend and Cancer-Specific Prevalence of Kidney Stones Among US Cancer Survivors, 2007-2020.Current oncology (Toronto, Ont.) · 2025Article
- Protective Effects of Phoenixin-14 Administration Against Renal Ischemia/Reperfusion Injury in Rats.Journal of biochemical and molecular toxicology · 2025Article
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- Development and Internal Validation of a Nomogram for Predicting Acute Kidney Injury After Cardiac Valve Surgery Using the Serum Uric Acid-to-Albumin Ratio.Journal of inflammation research · 2025Article
- Risk factors and renal outcomes of AKI in children with secondary steroid-resistant nephrotic syndrome.Renal failure · 2024Article
- Effects of High-Fructose Corn Syrup Addition to Broiler Diets on Performance, Carcass Yield, Visceral Weights, Gut pH and Some Blood Parameters.Veterinary medicine and science · 2024Article
- Treatment with Rasburicase in Hospitalized Patients with Cardiorenal Syndrome: Old Treatment, New Scenario.International journal of molecular sciences · 2024Article
- Establishment and evaluation of a nomogram prediction model for the risk of vascular calcification in stage 5 chronic kidney disease patients.Scientific reports · 2024Article
- Acute Toxicity and Antioxidant and Antibacterial Activities ofJournal of toxicology · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Acute kidney injury causes great morbidity and mortality in both the community and hospital settings. Understanding the etiological factors and the pathophysiological principles resulting in acute kidney injury is essential in prompting appropriate therapies. Recently hyperuricemia has been recognized as a potentially modifiable risk factor for acute kidney injury, including that associated with cardiovascular surgery, radiocontrast administration, rhabdomyolysis, and associated with heat stress. This review discussed the evidence that repeated episodes of acute kidney injury from heat stress and dehydration may also underlie the pathogenesis of the chronic kidney disease epidemic that is occurring in Central America (Mesoamerican nephropathy). Potential mechanisms for how uric acid might contribute to acute kidney injury are also discussed, including systemic effects on renal microvasculature and hemodynamics, and local crystalline and noncrystalline effects on the renal tubules. Pilot clinical trials also show potential benefits of lowering uric acid on acute kidney injury associated with a variety of insults. In summary, there is mounting evidence that hyperuricemia may have a significant role in the development of acute kidney injury. Prospective, placebo controlled, randomized trials are needed to determine the potential benefit of uric acid lowering therapy on kidney and cardio-metabolic diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.