Evidence map›Paper›PMID 28748035›Full record

ArticleJournal of oral microbiology2017

Cytokine response patterns to complex biofilms by mononuclear cells discriminate patient disease status and biofilm dysbiosis.

I M Velsko, Y Cruz-Almeida, H Huang, S M Wallet, L M Shaddox

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

I M VelskoDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
Y Cruz-AlmeidaInstitute for Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
H HuangDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
S M WalletDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA.
L M ShaddoxDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
University of Florida · USInstitute on Aging · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Comprehensive Training Program in Oral BiologyT90DE021990 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2011 to 2026
$8.2M
Mechanisms and Treatment Response of Aggressive Periodontitis in ChildrenR01DE019456 · NIDCR · UNIVERSITY OF FLORIDA · PI AUKHIL, IKRAMUDDIN, SHADDOX, LUCIANA MACCHION · 2009 to 2018
$5.6M
Role of the Spx Regulator in Streptococcus mutansR01DE019783 · NIDCR · UNIVERSITY OF ROCHESTER · PI LEMOS, JOSE A · 2010 to 2020
$3.7M
Tissue-Targeted Enzyme for Localized Tryptophan Catabolism to Direct Subcutaneous and Oral Mucosal Inflammatory ResponsesR01DE027301 · NIDCR · UNIVERSITY OF FLORIDA · PI KESELOWSKY, BENJAMIN GEORGE · 2017 to 2020
$2.0M
Neuroimaging Age-Related Changes i Pain ModulationK01AG048259 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2015 to 2019
$831k
NIA NIH HHS K01 AG048259NIA NIH HHS P30 AG028740NIDCR NIH HHS R01 DE019456NIDCR NIH HHS R01 DE019783NIDCR NIH HHS R01 DE027301NIDCR NIH HHS T90 DE021990
6 · The paper itself

Abstract

Localized aggressive periodontitis (LAP) is a rare form of periodontal disease with site-specific rapid tissue destruction. A lipopolysaccharide (LPS) hyper-inflammatory response was shown in LAP using peripheral whole blood, although responses to other bacterial surface components or complex oral biofilms have not been evaluated. Peripheral blood mononuclear cells (PBMCs) from 14 LAP patients, 15 healthy siblings (HS), and 13 unrelated healthy controls (HC) were stimulated with: LPS, lipoteichoic acid, or peptidoglycan; intact or sonically dispersed

Indexed as

biofilm homeostasiscytokinehost–pathogen interactioninflammatory responselocalized aggressive periodontitisPeriodontal diseasesubgingival biofilm

Identifiers

PMID28748035
PMCPMC5508357
OpenAlexW2625937462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.