ArticleFood & nutrition research2017
Polysaccharide from wheat bran induces cytokine expression via the toll-like receptor 4-mediated p38 MAPK signaling pathway and prevents cyclophosphamide-induced immunosuppression in mice.
Article in Food & nutrition research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- Investigation of the Immunomodulatory Effects of Combined Prebiotic, Probiotic, and Postbiotic Mixtures in Chicken Ileal Explant Cultures.Animals : an open access journal from MDPI · 2026Article
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- Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway.Scientific reports · 2025Article
- FOS as a biomarker for myocardial infarction treatment with Deng's Yangxin Decoction: a systems biology-based analysis.Frontiers in cardiovascular medicine · 2025Article
- VBNC Cronobacter sakazakii survives in macrophages by resisting oxidative stress and evading recognition by macrophages.BMC microbiology · 2024Article
- Immunostimulatory Effects of Gamisoyosan on Macrophages via TLR4-Mediated Signaling Pathways.Nutrients · 2024Article
- Immunomodulatory Effect ofMolecules (Basel, Switzerland) · 2024Article
- Article
- Fuzi polysaccharides improve immunity in immunosuppressed mouse models by regulating gut microbiota composition.Heliyon · 2023Article
- Antioxidant, Immunostimulatory, and Anticancer Properties of Hydrolyzed Wheat Bran Mediated through Macrophages Stimulation.International journal of molecular sciences · 2023Article
- Microanalysis Characterization and Immunomodulatory Effect for Selenium-Enriched Polysaccharide fromMolecules (Basel, Switzerland) · 2023Article
- Characterization and Immunological Activity of Exopolysaccharide fromFoods (Basel, Switzerland) · 2022Article
- Cereals as a Source of Bioactive Compounds with Anti-Hypertensive Activity and Their Intake in Times of COVID-19.Foods (Basel, Switzerland) · 2022Review
- Understanding immune-modulatory efficacy in vitro.Chemico-biological interactions · 2022Review
- Immune-Enhancing Effect of Submerged Culture ofInternational journal of molecular sciences · 2022Article
- Immunomodulatory functional foods and their molecular mechanisms.Experimental & molecular medicine · 2022Review
- Immune-Enhancing Effects ofJournal of microbiology and biotechnology · 2021Article
- Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19.Trends in food science & technology · 2021Review
- 20-Hydroxy-3-Oxolupan-28-Oic Acid, a Minor Component FromFrontiers in bioengineering and biotechnology · 2021Article
- A Novel Polysaccharide Isolated From Fresh Longan (Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wheat bran-derived polysaccharides have attracted particular attention due to their immunomodulatory effects. However, the molecular mechanisms underlying their functions are poorly understood. The current study was designed to examine the effect of wheat bran polysaccharide (WBP) on RAW 264.7 cells and the underlying signaling pathways, which have not been explored. In addition, we also investigated the immuno-enhancement effects of WBP on cyclophosphamide (CTX)-induced immunosuppression in mice. WBP significantly increased the concentrations of intracellular nitric oxide (NO) and cytokines such as prostaglandin E
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.