Evidence map›Paper›PMID 28747768›Full record

ArticleScientific reports2017

Controlling Adult Stem Cell Behavior Using Nanodiamond-Reinforced Hydrogel: Implication in Bone Regeneration Therapy.

Settimio Pacelli, Ryan Maloney, Aparna R Chakravarti, Jonathan Whitlow, Sayantani Basu, Saman Modaresi, Stevin Gehrke, Arghya Paul

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Diamond Chemistry: Advances and Perspectives.Angewandte Chemie (International ed. in English) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Settimio PacelliBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Ryan MaloneyBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Aparna R ChakravartiBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Jonathan WhitlowBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Sayantani BasuBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Saman ModaresiBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Stevin GehrkeDepartment of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, 66045, USA.
Arghya PaulBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering graduate program, School of Engineering, University of Kansas, Lawrence, KS, 66045, USA. arghyapaul@ku.edu.ORCID 0000-0003-4788-0378

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HOLMSTROM, ERIK D · 2012 to 2021
$22.1M
NIGMS NIH HHS P20 GM103638
6 · The paper itself

Abstract

Nanodiamonds (NDs) have attracted considerable attention as drug delivery nanocarriers due to their low cytotoxicity and facile surface functionalization. Given these features, NDs have been recently investigated for the fabrication of nanocomposite hydrogels for tissue engineering. Here we report the synthesis of a hydrogel using photocrosslinkable gelatin methacrylamide (GelMA) and NDs as a three-dimensional scaffold for drug delivery and stem cell-guided bone regeneration. We investigated the effect of different concentration of NDs on the physical and mechanical properties of the GelMA hydrogel network. The inclusion of NDs increased the network stiffness, which in turn augmented the traction forces generated by human adipose stem cells (hASCs). We also tested the ability of NDs to adsorb and modulate the release of a model drug dexamethasone (Dex) to promote the osteogenic differentiation of hASCs. The ND-Dex complexes modulated gene expression, cell area, and focal adhesion number in hASCs. Moreover, the integration of the ND-Dex complex within GelMA hydrogels allowed a higher retention of Dex over time, resulting in significantly increased alkaline phosphatase activity and calcium deposition of encapsulated hASCs. These results suggest that conventional GelMA hydrogels can be coupled with conjugated NDs to develop a novel platform for bone tissue engineering.

Indexed as

Cell DifferentiationHydrogel, Polyethylene Glycol DimethacrylateNanodiamondsAdult Stem CellsBone RegenerationDexamethasoneHumansTissue EngineeringDexamethasoneHydrogel, Polyethylene Glycol DimethacrylateNanodiamonds

Identifiers

PMID28747768
PMCPMC5529511

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.