Evidence map›Paper›PMID 28747766›Full record

ArticleScientific reports2017

DNA methylation signatures of chronic alcohol dependence in purified CD3

Christof Brückmann, Sumaiya A Islam, Julia L MacIsaac, Alexander M Morin, Kathrin N Karle, Adriana Di Santo, Richard Wüst, Immanuel Lang, Anil Batra, Michael S Kobor and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Validation ofInternational journal of molecular sciences · 2025
    Article
  5. Article
  6. International journal of molecular sciences · 2025
    Article
  7. Epigenetic regulation ofFrontiers in psychiatry · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Christof BrückmannDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Sumaiya A IslamDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Julia L MacIsaacCentre for Molecular Medicine and Therapeutics, BC Children's Hospital, Vancouver, BC, Canada.
Alexander M MorinCentre for Molecular Medicine and Therapeutics, BC Children's Hospital, Vancouver, BC, Canada.
Kathrin N KarleDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Adriana Di SantoDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Richard WüstDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Immanuel LangDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Anil BatraDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Michael S KoborDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-4140-1743
Vanessa NieratschkerDepartment of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany. vanessa.nieratschker@med.uni-tuebingen.de.
University of Tübingen · DEBC Children's Hospital · CACanadian Institute for Advanced Research · CAHertie Institute for Clinical Brain Research · DESTZ eyetrial · DEUniversity of British Columbia · CA

Funding

CIHR EGM-141897
6 · The paper itself

Abstract

Several studies have shown an association of alcohol dependence with DNA methylation (DNAm), suggesting that environmentally-induced changes on epigenomic variation may play an important role in alcohol dependence. In the present study, we analysed genome-wide DNAm profiles of purified CD3

Indexed as

DNA MethylationAdultAlcoholismCD3 ComplexEpigenesis, GeneticHumansMaleMiddle AgedT-Lymphocyte SubsetsCD3 Complex

Identifiers

PMID28747766
PMCPMC5529570
OpenAlexW2738667812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.