ArticleScientific reports2017
Spleen contributes to restraint stress induced changes in blood leukocytes distribution.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A meta-analysis of the association between post-traumatic stress disorder and cancer risk.Frontiers in psychiatry · 2023Pooled it
- Immunity in Rodent Models of Stress.Biological psychiatry · 2026Review
- Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota.European journal of immunology · 2026Article
- Transport Stress Induces Neuroimmune Dysregulation and Exacerbates Mycobacterium Tuberculosis Infection in Mice.International journal of molecular sciences · 2026Article
- Dynamic impacts of COVID-19 on immune cells and inflammatory indicators in Chinese medical health workers: a retrospective longitudinal study.Frontiers in cellular and infection microbiology · 2026Article
- Saikosaponin A Alleviates Hepatocellular Carcinoma Growth Induced by Chronic Stress via Regulating Tumor Immune Microenvironment.Journal of inflammation research · 2026Article
- Chronic stress promotes pancreatic ductal adenocarcinoma progression via complement C5a-recruited myeloid-derived suppressor cells.Cancer immunology, immunotherapy : CII · 2025Article
- Restraint Stress-Induced Neutrophil Inflammation Contributes to Concurrent Gastrointestinal Injury in Mice.International journal of molecular sciences · 2024Article
- Relationship between muscle sympathetic nerve activity and rapid increases in circulating leukocytes during experimental muscle pain.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Association between immune cells in peripheral blood and psychiatric symptoms.Frontiers in psychiatry · 2023Article
- Comparison of peripheral blood T, B, and NK lymphocytes between frontline medical workers for treating patients of COVID-19 and normal outpatient and emergency medical workers in China.Frontiers in psychiatry · 2023Article
- Discrete role for maternal stress and gut microbes in shaping maternal and offspring immunity.Neurobiology of stress · 2022Article
- The dynamic changes of cellular immunity among frontline medical workers who supported Wuhan for fighting against the COVID-19.International immunopharmacology · 2022Article
- Immunophenotype Rearrangement in Response to Tumor Excision May Be Related to the Risk of Biochemical Recurrence in Prostate Cancer Patients.Journal of clinical medicine · 2021Article
- Association between cellular immune response and spleen weight in mice with hepatocellular carcinoma.Oncology letters · 2021Article
- Immune response of frontline medical workers providing medical support for Wuhan COVID-19 patients, China.International immunopharmacology · 2021Article
- Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine.European archives of psychiatry and clinical neuroscience · 2021Article
- Effect of Selenium on Quantitative Structural Changes in Dexamethasone-Induced Immunodeficiency Rat Models.Iranian journal of medical sciences · 2021Article
- Effects of noise and low-concentration carbon monoxide exposure on rat immunity.Journal of occupational health · 2021Article
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Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychological stress has great impacts on the immune system, particularly the leukocytes distribution. Although the impacts of acute stress on blood leukocytes distribution are well studied, however, it remains unclear how chronic stress affects leukocytes distribution in peripheral circulation. Furthermore, there is no report about the role of spleen in the blood leukocytes distribution induced by stress. Here we show that spleen contributes to the alteration of restraint stress induced blood leukocytes distribution. Our data confirmed that restraint stress induced anxiety-like behavior in mice. Furthermore, we found that restraint stress decreased the CD4/CD8 ratio and elevated the percentages of natural killer cells, monocytes and polymorphonuclear myeloid-derived suppressor cell. We demonstrated that activation of hypothalamic-pituitary-adrenal axis (HPA) and sympathetic nervous system (SNS) contributes to restraint stress induced alteration of blood leukocyte distribution. Interestingly, we found that splenectomy could reverse the change of CD4/CD8 ratio induced by restraint stress. Together, our findings suggest that activation of HPA axis and SNS was responsible for the blood leukocyte subsets changes induced by restraint stress. Spleen, at least in part, contributed to the alteration in peripheral circulation induced by restraint stress.
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