Evidence map›Paper›PMID 28747676›Full record

ArticleScientific reports2017

Uremia does not affect neointima formation in mice.

Annemarie Aarup, Carsten H Nielsen, Line S Bisgaard, Ilze Bot, Henrik H El-Ali, Andreas Kjaer, Lars B Nielsen, Tanja X Pedersen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Annemarie AarupDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Carsten H NielsenDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Line S BisgaardDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ilze BotDivision of Biopharmaceutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.ORCID 0000-0002-1242-1959
Henrik H El-AliDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Andreas KjaerDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2706-5547
Lars B NielsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Tanja X PedersenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. txp@gubra.dk.
University of Copenhagen · DKLeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerotic cardiovascular disease is a major complication of chronic kidney disease (CKD). CKD leads to uremia, which modulates the phenotype of aortic smooth muscle cells (SMCs). Phenotypic modulation of SMCs plays a key role in accelerating atherosclerosis. We investigated the hypothesis that uremia potentiates neointima formation in response to vascular injury in mice. Carotid wire injury was performed on C57BL/6 wt and apolipoprotein E knockout (Apoe

Indexed as

NeointimaAnimalsApolipoproteins EAtherosclerosisCarotid Artery InjuriesHistocytochemistryMagnetic Resonance ImagingMice, Inbred C57BLMice, KnockoutMuscle CellsRenal InsufficiencyUremiaApolipoproteins E

Identifiers

PMID28747676
PMCPMC5529519
OpenAlexW2736623397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.