Evidence map›Paper›PMID 28747670›Full record

ArticleScientific reports2017

PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.

Khaled Alharshawi, Alejandra Marinelarena, Prabhakaran Kumar, Osama El-Sayed, Palash Bhattacharya, Zuoming Sun, Alan L Epstein, Ajay V Maker, Bellur S Prabhakar

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Decoding TNF receptor superfamily control of CD4Cell communication and signaling : CCS · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Identification of a Novel OX40LScientific reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Khaled AlharshawiDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Alejandra MarinelarenaDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Prabhakaran KumarDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Osama El-SayedDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Palash BhattacharyaDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Zuoming SunDepartment of Immunology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Alan L EpsteinDepartment of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Ajay V MakerDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.
Bellur S PrabhakarDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA. bprabhak@uic.edu.
Illinois College · USCity of Hope · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · USUniversity of Southern California · US

Funding

G-BMDC-induced Treg mediated suppression of Type 1 Diabetes in NOD miceR01AI107516 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PRABHAKAR, BELLUR S · 2014 to 2017
$1.6M
Enhancing anti-tumor immune responses in colon cancer metastasesK08CA190855 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAKER, AJAY V. · 2014 to 2018
$909k
Use of Bispecific Antibody for Treating Non-obese DiabetesR41AI085677 · NIAID · TOLEROGENICS, INC. · PI PRABHAKAR, BELLUR S · 2011 to 2011
$193k
NCI NIH HHS K08 CA190855NIAID NIH HHS R01 AI107516NIAID NIH HHS R41 AI085677
6 · The paper itself

Abstract

We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3

Indexed as

Cell ProliferationAnimalsInterleukin-2Membrane GlycoproteinsMiceMice, KnockoutNF-kappa BOX40 LigandProtein Kinase C-thetaReceptors, OX40T-Lymphocytes, RegulatoryTumor Necrosis FactorsInterleukin-2Membrane GlycoproteinsNF-kappa BOX40 LigandPrkcq protein, mouseProtein Kinase C-thetaReceptors, OX40Tnfrsf4 protein, mouseTnfsf4 protein, mouseTumor Necrosis Factors

Identifiers

PMID28747670
PMCPMC5529425
OpenAlexW2737934247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.