ArticleNature communications2017
Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
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- Subunit-specific behavioral modulation of sensory tuning in the visual cortex.PLoS computational biology · 2026Article
- Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies.PLoS computational biology · 2026Article
- Fluorescence microscopy through scattering media with robust matrix factorization.Cell reports methods · 2025Article
- Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli.PLoS computational biology · 2025Article
- FOUNDATIONS OF VISUAL FORM SELECTIVITY IN MACAQUE AREAS V1 AND V2.bioRxiv : the preprint server for biology · 2025Article
- Article
- Sparse high-dimensional decomposition of non-primary auditory cortical receptive fields.PLoS computational biology · 2025Article
- Stimulus-invariant aspects of the retinal code drive discriminability of natural scenes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Fixational eye movements enhance the precision of visual information transmitted by the primate retina.Nature communications · 2024Article
- Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.PLoS computational biology · 2024Article
- Fixational Eye Movements Enhance the Precision of Visual Information Transmitted by the Primate Retina.bioRxiv : the preprint server for biology · 2024Article
- The Dynamic Sensorium competition for predicting large-scale mouse visual cortex activity from videos.ArXiv · 2024Article
- Article
- What does the mean mean? A simple test for neuroscience.PLoS computational biology · 2024Article
- Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Electrophysiological dataset from macaque visual cortical area MST in response to a novel motion stimulus.Scientific data · 2022Article
- Representing the dynamics of high-dimensional data with non-redundant wavelets.Patterns (New York, N.Y.) · 2022Article
- Simple model for encoding natural images by retinal ganglion cells with nonlinear spatial integration.PLoS computational biology · 2022Article
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8 authors.
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Abstract
Neurons in sensory systems often pool inputs over arrays of presynaptic cells, giving rise to functional subunits inside a neuron's receptive field. The organization of these subunits provides a signature of the neuron's presynaptic functional connectivity and determines how the neuron integrates sensory stimuli. Here we introduce the method of spike-triggered non-negative matrix factorization for detecting the layout of subunits within a neuron's receptive field. The method only requires the neuron's spiking responses under finely structured sensory stimulation and is therefore applicable to large populations of simultaneously recorded neurons. Applied to recordings from ganglion cells in the salamander retina, the method retrieves the receptive fields of presynaptic bipolar cells, as verified by simultaneous bipolar and ganglion cell recordings. The identified subunit layouts allow improved predictions of ganglion cell responses to natural stimuli and reveal shared bipolar cell input into distinct types of ganglion cells.How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.
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