ArticleNature communications2017
Anterior cingulate is a source of valence-specific information about value and uncertainty.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Differentiating the abnormalities of food and monetary reward cue processing associated with overweight/obesity: an ALE meta-analysis.International journal of obesity (2005) · 2026Pooled it
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- Histamine HMolecular psychiatry · 2026Article
- Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering.Nature neuroscience · 2026Article
- Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior.Nature communications · 2026Article
- Neural adaptation to expected uncertainty in neurotypical adults and high-functioning adults with autism spectrum disorder.Cognitive, affective & behavioral neuroscience · 2026Article
- Cortical-limbic circuit dynamics of approach-avoidance conflict in humans.Nature communications · 2026Article
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- Awareness of being: a computational neurophenomenological model of mindfulness, mind-wandering, and meta-attentional control.Neuroscience of consciousness · 2026Article
- Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats.Frontiers in aging neuroscience · 2026Article
- sEEG-based brain-computer interfacing in a large adult and pediatric cohort.Journal of neural engineering · 2025Article
- Prefrontal inhibitory mechanisms associated with Putamen activity during valence learning revealed by multimodal fMRI-fMRS.Communications biology · 2025Article
- Tachykinin 1-expressing neurons in the lateral habenula signal negative reward prediction error.bioRxiv : the preprint server for biology · 2025Article
- Article
- Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning.bioRxiv : the preprint server for biology · 2025Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- Intersect between brain mechanisms of conditioned threat, active avoidance, and reward.Communications psychology · 2025Review
- Examining motivational profiles in the dark personality tetrad using an approach-avoidance conflict task.PloS one · 2025Article
25 more citing papers are in PubMed but not listed here.
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Abstract
Anterior cingulate cortex (ACC) is thought to control a wide range of reward, punishment, and uncertainty-related behaviors. However, how it does so is unclear. Here, in a Pavlovian procedure in which monkeys displayed a diverse repertoire of reward-related, punishment-related, and uncertainty-related behaviors, we show that many ACC-neurons represent expected value and uncertainty in a valence-specific manner, signaling value or uncertainty predictions about either rewards or punishments. Other ACC-neurons signal prediction information about rewards and punishments by displaying excitation to both (rather than excitation to one and inhibition to the other). This diversity in valence representations may support the role of ACC in many behavioral states that are either enhanced by reward and punishment (e.g., vigilance) or specific to either reward or punishment (e.g., approach and avoidance). Also, this first demonstration of punishment-uncertainty signals in the brain suggests that ACC could be a target for the treatment of uncertainty-related disorders of mood.Rewards or punishments elicit diverse behavioral responses; however, the neural circuits underlying such flexibility are unclear. Here Monosov shows that this diversity could be supported by neurons in the anterior cingulate that represent expected value and uncertainty in a valence-specific manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.