ArticleNature communications2017
Coupled symmetric and asymmetric circuits underlying spatial orientation in fruit flies.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A computational model for angular velocity integration in a locust heading circuit.PLoS computational biology · 2024Article
- Maintaining and updating accurate internal representations of continuous variables with a handful of neurons.Nature neuroscience · 2024Article
- Estimating orientation in natural scenes: A spiking neural network model of the insect central complex.PLoS computational biology · 2024Article
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- Global inhibition in head-direction neural circuits: a systematic comparison between connectome-based spiking neural circuit models.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- A unifying perspective on neural manifolds and circuits for cognition.Nature reviews. Neuroscience · 2023Review
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- Sensory feedback expands dynamic complexity and aids in robustness against noise.Biological cybernetics · 2022Article
- Online learning for orientation estimation during translation in an insect ring attractor network.Scientific reports · 2022Article
- From Photons to Behaviors: Neural Implementations of Visual Behaviors inFrontiers in neuroscience · 2022Review
- Plasticity between visual input pathways and the head direction system.Current opinion in neurobiology · 2021Review
- A connectome of theeLife · 2021Article
- Integration of sleep homeostasis and navigation in Drosophila.PLoS computational biology · 2021Article
- Comprehensive map of visual projection neurons for processing ultraviolet information in the Drosophila brain.The Journal of comparative neurology · 2021Article
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- Autonomous Flying With Neuromorphic Sensing.Frontiers in neuroscience · 2021Article
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- Identification ofOpen biology · 2020Article
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5 authors.
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Abstract
Maintaining spatial orientation when carrying out goal-directed movements requires an animal to perform angular path integration. Such functionality has been recently demonstrated in the ellipsoid body (EB) of fruit flies, though the precise circuitry and underlying mechanisms remain unclear. We analyze recently published cellular-level connectomic data and identify the unique characteristics of the EB circuitry, which features coupled symmetric and asymmetric rings. By constructing a spiking neural circuit model based on the connectome, we reveal that the symmetric ring initiates a feedback circuit that sustains persistent neural activity to encode information regarding spatial orientation, while the asymmetric rings are capable of integrating the angular path when the body rotates in the dark. The present model reproduces several key features of EB activity and makes experimentally testable predictions, providing new insight into how spatial orientation is maintained and tracked at the cellular level.Ellipsoid body (EB) neurons in the fruit fly represent the animal heading through a bump-like activity dynamics. Here the authors report a connectome-driven spiking neural circuit model of the EB and the protocerebral bridge (PB) that can maintain and update an activity bump related to the spatial orientation.
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