ArticleProceedings of the National Academy of Sciences of the United States of America2017
Detection and quantification of inbreeding depression for complex traits from SNP data.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.American journal of human genetics · 2023Pooled it
- Pooled it
- Associations of autozygosity with a broad range of human phenotypes.Nature communications · 2019Pooled it
- Bony fish genomes: Status and gaps.Journal of fish biology · 2026Review
- Allelic association analyses: estimation recommendations.Genetics · 2026Article
- Estimation of Inbreeding Depression From Overdominant Loci Using Molecular Markers.Evolutionary applications · 2025Article
- Genomic and Conventional Inbreeding Coefficient Estimation Using Different Estimator Models in Korean Duroc, Landrace, and Yorkshire Breeds Using 70K Porcine SNP BeadChip.Animals : an open access journal from MDPI · 2024Article
- Genomic Reconstruction of the Successful Establishment of a Feralized Bovine Population on the Subantarctic Island of Amsterdam.Molecular biology and evolution · 2024Article
- Detecting inbreeding depression in structured populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Inbreeding depression is associated with recent homozygous-by-descent segments in Belgian Blue beef cattle.Genetics, selection, evolution : GSE · 2024Article
- An empirical evaluation of the estimation of inbreeding depression from molecular markers under suboptimal conditions.Evolutionary applications · 2023Article
- The coefficients of inbreeding revealed by ROH study among inbred individuals belonging to each type of the first cousin marriage: A preliminary report from North India.Genes & genomics · 2023Article
- Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish.BMC genomics · 2023Article
- A comparison of marker-based estimators of inbreeding and inbreeding depression.Genetics, selection, evolution : GSE · 2022Article
- Fine-tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book: the case of the Pura Raza Española horse.Journal of animal science and biotechnology · 2022Article
- Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample.Behavior genetics · 2022Article
- Limiting distribution of X-chromosomal coalescence times under first-cousin consanguineous mating.Theoretical population biology · 2022Article
- From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill.Nature genetics · 2022Review
- Rank-invariant estimation of inbreeding coefficients.Heredity · 2022Article
- Genomic partitioning of inbreeding depression in humans.American journal of human genetics · 2021Article
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Abstract
Quantifying the effects of inbreeding is critical to characterizing the genetic architecture of complex traits. This study highlights through theory and simulations the strengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding depression (ID). We demonstrate that heterogeneity in linkage disequilibrium (LD) between causal variants and SNPs biases ID estimates, and we develop an approach to correct this bias using LD and minor allele frequency stratified inference (LDMS). We quantified ID in 25 traits measured in [Formula: see text] participants of the UK Biobank, using LDMS, and confirmed previously published ID for 4 traits. We find unique evidence of ID for handgrip strength, waist/hip ratio, and visual and auditory acuity (ID between -2.3 and -5.2 phenotypic SDs for complete inbreeding; [Formula: see text]). Our results illustrate that a careful choice of the measure of inbreeding combined with LDMS stratification improves both detection and quantification of ID using SNP data.
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