Evidence map›Paper›PMID 28747508›Full record

ArticleJournal of virology2017

Mutations in the E2 Glycoprotein and the 3' Untranslated Region Enhance Chikungunya Virus Virulence in Mice.

David W Hawman, Kathryn S Carpentier, Julie M Fox, Nicholas A May, Wes Sanders, Stephanie A Montgomery, Nathaniel J Moorman, Michael S Diamond, Thomas E Morrison

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

David W HawmanDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Kathryn S CarpentierDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Julie M FoxDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nicholas A MayDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Wes SandersDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stephanie A MontgomeryDepartment of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Nathaniel J MoormanDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Thomas E MorrisonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA thomas.morrison@ucdenver.edu.
University of Colorado Denver · USUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · US

Funding

The role of host and viral translation factors during HCMV infectionR01AI103311 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOORMAN, NATHANIEL J · 2013 to 2022
$3.9M
Structural and functional basis of ultra potent CHKV neutralization by human mAbsR01AI114816 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2015 to 2019
$3.7M
ISG CONTROL OF FLAVIVIRUS INFECTIONR01AI104972 · NIAID · WASHINGTON UNIVERSITY · PI CHANDA, SUMIT K, DIAMOND, MICHAEL S · 2013 to 2017
$3.0M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Mechanisms of immune suppression during arthritogenic alphavirus infectionsR01AI108725 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MORRISON, THOMAS E · 2014 to 2018
$1.9M
Hybrid Sequencing to Define the Full-Length Transcriptome of Double Stranded DNA VirusesR21AI123811 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOORMAN, NATHANIEL J, PRINS, JAN F · 2016 to 2017
$413k
NIAID NIH HHS R01 AI103311NIAID NIH HHS R01 AI104972NIAID NIH HHS R01 AI108725NIAID NIH HHS R01 AI114816NIAID NIH HHS R21 AI123811NIAID NIH HHS T32 AI052066
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection. Although studies of humans and experimentally infected animals suggest that CHIKV infection persists in musculoskeletal tissues, the mechanisms for this remain poorly understood. To evaluate this further, we isolated CHIKV from the serum of persistently infected

Indexed as

alphaviruschikungunya virusviral pathogenesisvirulence determinants

Identifiers

PMID28747508
PMCPMC5625495
OpenAlexW2739390904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.