Evidence map›Paper›PMID 28747497›Full record

ArticleJournal of virology2017

Genetic Stability of Parainfluenza Virus 5-Vectored Human Respiratory Syncytial Virus Vaccine Candidates after

Shannon I Phan, Carolyn M Adam, Zhenhai Chen, Michael Citron, Xiaoping Liang, Amy S Espeseth, Dai Wang, Biao He

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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  11. Respiratory Syncytial Virus Vaccine Approaches: a Current Overview.Current clinical microbiology reports · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Shannon I PhanDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
Carolyn M AdamGeorgia Department of Public Health, Acute Disease Epidemiology Section, Atlanta, Georgia, USA.
Zhenhai ChenCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Michael CitronVaccines Early Discovery, Merck Research Laboratories, West Point, Pennsylvania, USA.
Xiaoping LiangVaccines Early Discovery, Merck Research Laboratories, West Point, Pennsylvania, USA.
Amy S EspesethVaccines Early Discovery, Merck Research Laboratories, West Point, Pennsylvania, USA.
Dai WangVaccines Early Discovery, Merck Research Laboratories, West Point, Pennsylvania, USA.ORCID http://orcid.org/0000-0001-5666-8622
Biao HeDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA bhe@uga.edu.
United States Military Academy · USUniversity of Georgia · USGeorgia Department of Public Health · USYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human respiratory syncytial virus (RSV) is the leading etiologic agent of lower respiratory tract infections in children, but no licensed vaccine exists. Previously, we developed two parainfluenza virus 5 (PIV5)-based RSV vaccine candidates that protect mice against RSV challenge. PIV5 was engineered to express either the RSV fusion protein (F) or the RSV major attachment glycoprotein (G) between the hemagglutinin-neuraminidase (HN) and RNA-dependent RNA polymerase (L) genes of the PIV5 genome [PIV5-RSV-F (HN-L) and PIV5-RSV-G (HN-L), respectively]. To investigate the stability of the vaccine candidates

Indexed as

AnimalsBronchoalveolar Lavage FluidCell LineChlorocebus aethiopsCricetinaeGenomic InstabilityGlycoproteinsHN ProteinParainfluenza Virus 5Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus VaccinesRNA-Dependent RNA PolymeraseVero CellsViral Fusion ProteinsGlycoproteinsHN ProteinRespiratory Syncytial Virus VaccinesRNA-Dependent RNA PolymeraseViral Fusion Proteinsgenome stabilityPIV5respiratory syncytial virusvaccine

Identifiers

PMID28747497
PMCPMC5599752
OpenAlexW2736742531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.