Evidence map›Paper›PMID 28747495›Full record

ArticleJournal of virology2017

Human Immunodeficiency Virus and Simian Immunodeficiency Virus Maintain High Levels of Infectivity in the Complete Absence of Mucin-Type O-Glycosylation.

James M Termini, Elizabeth S Church, Zachary A Silver, Stuart M Haslam, Anne Dell, Ronald C Desrosiers

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

James M TerminiDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Elizabeth S ChurchDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Zachary A SilverDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Stuart M HaslamDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Anne DellDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Ronald C DesrosiersDepartment of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA r.desrosiers@med.miami.edu.ORCID http://orcid.org/0000-0001-6851-3003
University of Miami · USImperial College London · GB

Funding

ZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROWLETT, JAMES K · 1985 to 2011
$139.3M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Functional Role of O-Glycosylation of HIV-1R01AI104523 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DESROSIERS, RONALD C · 2013 to 2024
$4.1M
MOLECULAR BASIS FOR SIV PATHOGENICITYR01AI025328 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DESROSIERS, RONALD C · 1987 to 2010
$2.0M
Biotechnology and Biological Sciences Research Council BB/F008309/1Biotechnology and Biological Sciences Research Council BBF0083091Biotechnology and Biological Sciences Research Council BBK0161641NCRR NIH HHS P51 RR000168NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI025328NIAID NIH HHS R01 AI104523Wellcome Trust
6 · The paper itself

Abstract

A highly conserved threonine near the C terminus of gp120 of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) was investigated for its contributions to envelope protein function and virion infectivity. When this highly conserved Thr residue was substituted with anything other than serine (the other amino acid that can accept O-glycosylation), the resulting virus was noninfectious. We found that this Thr was critical for the association of gp120 with the virion and that amino acid substitution increased the amount of dissociated gp120 in the cell culture supernatant. When HIV virions were generated in cells overexpressing polypeptide

Indexed as

Amino Acid SubstitutionCell LineGalactokinaseGene Knockout TechniquesGlycosylationHEK293 CellsHIVHIV Envelope Protein gp120HIV InfectionsHumansMucinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseSimian Immunodeficiency VirusViral Envelope ProteinsGalactokinaseGALK1 protein, humanGALK2 protein, humanHIV Envelope Protein gp120MucinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseViral Envelope Proteinsenvelopeglycosylationgp120human immunodeficiency virusinfectivityO-linked glycosylationsimian immunodeficiency virus

Identifiers

PMID28747495
PMCPMC5599749
OpenAlexW2737176950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.