Evidence map›Paper›PMID 28747479›Full record

ArticleProceedings. Biological sciences2017

A nutrient mediates intraspecific competition between rodent malaria parasites

Nina Wale, Derek G Sim, Andrew F Read

Open access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  12. The contribution of host cell-directed vs. parasite-directed immunity to the disease and dynamics of malaria infections.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  13. Review
  14. Article
  15. Article
  16. Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nina WaleCenter for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA nwale@umich.edu.ORCID http://orcid.org/0000-0001-9703-444X
Derek G SimCenter for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Andrew F ReadCenter for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.ORCID http://orcid.org/0000-0001-7604-7903
Pennsylvania State University · US

Funding

The evolutionary biology of chemotherapy against infectious agents: towards ratiR01GM089932 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI READ, ANDREW F. · 2010 to 2013
$1.1M
NIGMS NIH HHS R01 GM089932
6 · The paper itself

Abstract

Hosts are often infected with multiple strains of a single parasite species. Within-host competition between parasite strains can be intense and has implications for the evolution of traits that impact patient health, such as drug resistance and virulence. Yet the mechanistic basis of within-host competition is poorly understood. Here, we demonstrate that a parasite nutrient, para-aminobenzoic acid (pABA), mediates competition between a drug resistant and drug susceptible strain of the malaria parasite,

Indexed as

Host-Parasite Interactions4-Aminobenzoic AcidAnimalsCoinfectionDrug ResistanceFemaleMalariaMice, Inbred C57BLParasite LoadPlasmodium chabaudiVirulence4-Aminobenzoic Acidco-infectiondiseasemalariaPlasmodium chabaudiresource competitionwithin-host dynamics

Identifiers

PMID28747479
PMCPMC5543226
OpenAlexW2739288505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.