Evidence map›Paper›PMID 28747460›Full record

ArticleStroke2017

Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice.

Nils Schallner, Judith-Lisa Lieberum, David Gallo, Robert H LeBlanc, Patrick M Fuller, Khalid A Hanafy, Leo E Otterbein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 51 citations in OpenAlex.

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  15. Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nils SchallnerFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.).
Judith-Lisa LieberumFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.).
David GalloFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.).
Robert H LeBlancFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.).
Patrick M FullerFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.).
Khalid A HanafyFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.).
Leo E OtterbeinFrom the Department of Surgery (N.S., J.-L.L., D.G., L.E.O.) and Department of Neurology (R.H.L., P.M.F., K.A.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Anesthesiology and Critical Care, Medical Center-University Freiburg, Faculty of Medicine, Germany (N.S., J.-L.L.); and Aston University, Birmingham, United Kingdom (L.E.O.). lotterbe@bidmc.harvard.edu.
University Medical Center Freiburg · DE

Funding

Molecular-Genetic Dissection of Subcortical Circuitry Regulating ArousalR01NS073613 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Patrick M Fuller · 2011 to 2026
$5.5M
Brainstem regulation of sleepR01NS092652 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FULLER, PATRICK M · 2015 to 2019
$2.2M
Endogenous Gas Molecules As Transcription FactorsR01GM088666 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI OTTERBEIN, LEO E · 2009 to 2012
$1.4M
Microglial Signal Transduction in Fever and Vasospasm after Subarachnoid HemorrhaK08NS078048 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HANAFY, KHALID A. · 2012 to 2016
$923k
The role of TLR4-dependent sterile inflammation in mediating adverse outcomes after SAHR21NS099606 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HANAFY, KHALID A. · 2017 to 2018
$476k
NIGMS NIH HHS R01 GM088666NINDS NIH HHS K08 NS078048NINDS NIH HHS R01 NS073613NINDS NIH HHS R01 NS092652NINDS NIH HHS R21 NS099606
6 · The paper itself

Abstract

background and purposeSubarachnoid hemorrhage (SAH) is associated with a temporal pattern of stroke incidence. We hypothesized that natural oscillations in gene expression controlling circadian rhythm affect the severity of neuronal injury. We moreover predict that heme oxygenase-1 (HO-1/

methodsMurine SAH model was used where blood was injected at various time points of the circadian cycle. Readouts included circadian clock gene expression, locomotor activity, vasospasm, neuroinflammatory markers, and apoptosis. In addition, cerebrospinal fluid and peripheral blood leukocytes from SAH patients and controls were analyzed for clock gene expression.

resultsSignificant elevations in the clock genes

conclusionsClock gene expression regulates, in part, the severity of SAH and requires myeloid HO-1 activity to clear the erythrocyte burden and inhibit neuronal apoptosis. Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH.

Indexed as

AnimalsApoptosisARNTL Transcription FactorsBasic Helix-Loop-Helix ProteinsCarbon MonoxideCerebrospinal FluidCircadian RhythmCLOCK ProteinsGene ExpressionHeme Oxygenase-1HumansImmunohistochemistryInflammationLeukocytesLocomotionMembrane ProteinsARNTL Transcription FactorsBasic Helix-Loop-Helix ProteinsBmal1 protein, mouseCarbon MonoxideClock protein, mouseCLOCK ProteinsHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsNerve Tissue ProteinsNpas2 protein, mousePer1 protein, mousePER2 protein, humanPer2 protein, mousePeriod Circadian Proteinscarbon monoxidecircadian rhythmmiceneuroprotectionsubarachnoid hemorrhage

Identifiers

PMID28747460
PMCPMC5575974
OpenAlexW2739002523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.