Trial reportNeurology2017
Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke.
Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Efficacy and Safety of Xingnaojing Injection for Emergency Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2022Pooled it
- The Role of Biomarkers in Atherothrombotic Stroke-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Association of Matrix Metalloproteinase 9 and Cellular Fibronectin and Outcome in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Association of Cardiac Biomarkers in Combination With Cognitive Impairment After Acute Ischemic Stroke.Journal of the American Heart Association · 2024Trial
- Mechanisms and biomarkers of poststroke cognitive impairment.Neural regeneration research · 2026Article
- Neuroprotective effect of 3',4'-dihydroxyflavonol on blood-brain barrier ıntegrity and matrix remodeling in rats with transient bilateral carotid occlusion-ınduced ıschemia-reperfusion.Journal of bioenergetics and biomembranes · 2026Article
- Next-Generation Stroke Biomarkers: Bridging the Gap Between Innovation and Translation.Journal of clinical medicine · 2026Review
- Unwinding the Neurovascular Unit: The Vascular Extracellular Matrix and Mechanochemical Collagen Functionalization in Vascular Dementia.International journal of molecular sciences · 2026Review
- Associations of plasma MMP-9 and MPO with functional outcome in moderate to severe acute ischemic stroke.Scientific reports · 2026Article
- Differential prognostic value of circulating biomarkers across small ischemic stroke subtypes.Scientific reports · 2026Article
- NIHSS and inflammatory biomarkers predict 90-day poor outcome in older patients with acute ischemic stroke.Biomolecules & biomedicine · 2026Observational
- Thromboembolic ischemic stroke induces neutrophil recruitment and matrix metalloproteinase-9 release to enhance ischemic brain injury.Research and practice in thrombosis and haemostasis · 2026Article
- Longitudinal plasma interleukin-6 and post-stroke cognitive outcomes: The Stroke-IMPaCT study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Circulating cfdna: A novel biomarker for preventing early recurrence in ischemic stroke.Journal of thrombosis and thrombolysis · 2026Review
- Verification of the predictive value of EV-associated biomarkers MMP9 and CEACAM1 in rehabilitation of ischemic stroke.Extracellular vesicles and circulating nucleic acids · 2026Article
- Review
- Matrix Metalloproteinase-9 and Postoperative Outcomes in Carotid Endarterectomy: A Systematic Review.Journal of clinical medicine · 2025Review
- A Single Bout of Physical Exercise Mimicking a Motor Seizure Increases Serum MMP-9, but Not S100B.International journal of molecular sciences · 2025Article
- Cellular and enzymatic features of thrombi in humans are vascular bed dependent.Blood vessels, thrombosis & hemostasis · 2025Article
- Advances in the detection of biomarkers for ischemic stroke.Frontiers in neurology · 2025Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 3 countries.
Chongke ZhongFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Jingyuan YangFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Tan XuFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Tian XuFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Yanbo PengFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Aili WangFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Jinchao WangFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Hao PengFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Qunwei LiFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Zhong JuFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Deqin GengFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China.
Yonghong ZhangFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China. yhzhang@suda.edu.cn jhe@tulane.edu.
Jiang HeFrom the Department of Epidemiology (C.Z., J.Y., T.X., Tan Xu, Tian Xu, A.W., H.P., Y.Z., J.H.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., Tan Xu, Y.Z., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Jiangsu; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Neurology (J.W.), Yutian County Hospital, Hebei; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Shandong; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Inner Mongolia; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Jiangsu, China. yhzhang@suda.edu.cn jhe@tulane.edu.
CATIS Investigators
Tulane University · US
Funding
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI JING CHEN · 2016 to 2026
$25.3MResearch Training in Gene-Environment Interaction in ChinaD43TW009107 · FIC · TULANE UNIVERSITY OF LOUISIANA · PI GU, DONGFENG, HE, JIANG · 2012 to 2016
$1.1MFIC NIH HHS D43 TW009107NIGMS NIH HHS P20 GM109036
Abstract
objectiveTo examine the association between serum matrix metalloproteinases-9 (MMP-9) levels and prognosis of acute ischemic stroke.
methodsWe measured serum MMP-9 levels in 3,186 participants (2,008 men and 1,178 women) from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Study outcome data on death, major disability (modified Rankin Scale score ≥3), and vascular disease were collected at 3 months after stroke onset.
resultsDuring 3 months of follow-up, 767 participants (24.6%) experienced major disability or died. Serum MMP-9 was significantly associated with an increased risk of death and major disability after adjustment for age, sex, time from onset to randomization, current smoking, alcohol drinking, admission NIH Stroke Scale score, diastolic blood pressure, plasma glucose, white blood cell counts, use of antihypertensive medications, and history of hypertension, coronary heart disease, and diabetes mellitus. For example, 1-SD (0.32 ng/mL) higher log-MMP-9 was associated with an odds ratio (95% confidence interval) of 1.16 (1.06-1.28) for the combined outcome of death and major disability, 1.12 (1.01-1.23) for major disability, and 1.29 (1.01-1.66) for death. The addition of serum MMP-9 to conventional risk factors improved risk prediction of the combined outcome of death or major disability (net reclassification index 9.1%,
conclusionsHigher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Indexed as
BiomarkersBrain IschemiaChinaDisability EvaluationFemaleFollow-Up StudiesHumansMaleMatrix Metalloproteinase 9Middle AgedMultivariate AnalysisOdds RatioPrognosisRegression AnalysisRisk AssessmentRisk FactorsBiomarkersMatrix Metalloproteinase 9MMP9 protein, human
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