Evidence map›Paper›PMID 28747373›Full record

ArticleJournal of clinical microbiology2017

Investigation of Respiratory Syncytial Virus Outbreak on an Adult Stem Cell Transplant Unit by Use of Whole-Genome Sequencing.

Yijun Zhu, Teresa R Zembower, Kristen E Metzger, Zhengdeng Lei, Stefan J Green, Chao Qi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Multiple Respiratory Syncytial Virus Introductions Into a Neonatal Intensive Care Unit.Journal of the Pediatric Infectious Diseases Society · 2021
    Article
  6. Observational
  7. Update on infection control practices in cancer hospitals.CA: a cancer journal for clinicians · 2018
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yijun ZhuDepartment of Pathology, University of Chicago, Chicago, Illinois, USA yijun.zhu@uchospitals.edu.
Teresa R ZembowerDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kristen E MetzgerDepartment of Healthcare Epidemiology and Infection Prevention, Northwestern Memorial Healthcare, Chicago, Illinois, USA.
Zhengdeng LeiResearch Resources Center, University of Illinois at Chicago, Chicago, Illinois, USA.
Stefan J GreenResearch Resources Center, University of Illinois at Chicago, Chicago, Illinois, USA.
Chao QiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Northwestern University · USUniversity of Illinois Chicago · USNorthwestern Medicine · USUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A viral whole-genome sequencing (WGS) strategy, based on PCR amplification followed by next-generation sequencing, was used to investigate a nosocomial respiratory syncytial virus-B (RSV-B) outbreak in a hematology-oncology and stem cell transplant unit. RSV-B genomes from 16 patients and health care workers (HCWs) suspected to be involved in the outbreak were compared to RSV-B genomes that were acquired from outpatients during the same time period but epidemiologically unrelated to the outbreak. Phylogenetic analysis of the whole genome identified a cluster of 11 patients and HCWs who had an identical RSV-B strain which was clearly distinct from strains recovered from individuals unrelated to the outbreak. Sequence variation of the glycoprotein (G) gene alone was insufficient to distinguish the outbreak strains from the outbreak-unrelated strains, thereby demonstrating that WGS is valuable for local outbreak investigation.

Indexed as

Disease OutbreaksAdultCross InfectionGenome, ViralHigh-Throughput Nucleotide SequencingHumansPolymerase Chain ReactionRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRetrospective StudiesStem Cell TransplantationTertiary Care Centersrespiratory syncytial viruswhole-genome sequencing

Identifiers

PMID28747373
PMCPMC5625381
OpenAlexW2738468372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.