Evidence map›Paper›PMID 28747348›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Lactation-Based Maternal Educational Immunity Crosses MHC Class I Barriers and Can Impart Th1 Immunity to Th2-Biased Recipients.

Mrinal K Ghosh, H Konrad Muller, Ameae M Walker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?International journal of molecular sciences · 2022
    Review
  6. Review
  7. Transgenerational transfer of gene-modified T cells.Journal for immunotherapy of cancer · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Mrinal K GhoshDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA 92521; and.
H Konrad MullerSchool of Medicine, University of Tasmania, Hobart 7000, Tasmania, Australia.
Ameae M WalkerDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA 92521; and ameae.walker@ucr.edu.
University of California, Riverside · USUniversity of Tasmania · AU

Funding

Immune Development: Role of Milk Cell Transfer and Recipient GenderR01HD065099 · NICHD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WALKER, AMEAE M · 2011 to 2015
$1.6M
NIAID NIH HHS HHSN272201300006CNICHD NIH HHS R01 HD065099
6 · The paper itself

Abstract

We have previously demonstrated lactational transfer of T cell-based immunity from dam to foster pup. In the short term, a significant part of transferred immunity is passive cellular immunity. However, as time progresses, this is replaced by what we have described as maternal educational immunity such that by young adulthood, all immune cells responding to a foster dam immunogen are the product of the foster pup's thymus. To reduce confounding factors, this original demonstration used congenic/syngeneic dam and foster pup pairs. In this study, we investigated lactational transfer of immunity to

Indexed as

Immunity, Maternally-AcquiredAnimalsFemaleForkhead Transcription FactorsHistocompatibility Antigens Class IIsoantigensLactationMiceMice, Inbred BALB CMice, Inbred C57BLMycobacterium tuberculosisPregnancyTh1 CellsTh1-Th2 BalanceTh2 CellsThymocytesForkhead Transcription FactorsFoxp3 protein, mouseHistocompatibility Antigens Class IIsoantigens

Identifiers

PMID28747348
PMCPMC5563164
OpenAlexW2737125818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.